Exploring synergies between B- and T-cell vaccine approaches to optimize immune responses against HIV-workshop report

被引：7

作者：

Maciel Jr, Milton ^{[1
]}

Amara, Rama R. ^{[2
]}

Bar, Katharine J. ^{[3
]}

Crotty, Shane ^{[4
,5
,6
]}

Deeks, Steven G. ^{[7
]}

Duplessis, Christopher ^{[1
]}

Gaiha, Gaurav ^{[8
]}

McElrath, M. Juliana ^{[9
]}

McMichael, Andrew ^{[10
]}

Palin, Amy ^{[1
]}

Rutishauser, Rachel ^{[11
]}

Shapiro, Stuart ^{[1
]}

Smiley, Stephen T. ^{[1
]}

D'Souza, M. Patricia ^{[1
]}

机构：

[1] NIAID, Div AIDS, NIH, Rockville, MD 20892 USA

[2] Emory Univ, Yerkes Natl Primate Res Ctr, Atlanta, GA USA

[3] Univ Penn, Dept Med, Philadelphia, PA USA

[4] La Jolla Inst Immunol LJI, Ctr Infect Dis & Vaccine Res, La Jolla, CA 92037 USA

[5] Univ Calif San Diego UCSD, Dept Med, Div Infect Dis & Global Publ Hlth, La Jolla, CA USA

[6] Div HIV Infect Dis & Global Med, San Francisco, CA USA

[7] Univ Calif San Francisco, Dept Med, San Francisco, CA USA

[8] MIT & Harvard, Ragon Inst Mass Gen, Cambridge, MA USA

[9] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA USA

[10] Univ Oxford, Nuffield Dept Clin Med, Oxford, England

[11] Univ Calif San Francisco, Dept Med, San Francisco, CA USA

来源：

NPJ VACCINES | 2024年 / 9卷 / 01期

基金：

美国国家卫生研究院;

关键词：

EFFICACY TRIAL; ANTIBODIES;

D O I：

10.1038/s41541-024-00818-y

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The US National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institute of Health (NIH), convened a virtual workshop on August 8-9th, 2023 to explore potential synergies between HIV vaccine approaches that are designed to induce cellular or humoral immune responses. The goal of this workshop was to review data on leading vaccine candidates and to discuss the best strategies for combining these approaches to optimize immunity against HIV. Here, we summarize the findings reviewed at the workshop and discuss the knowledge gaps and priorities for future studies that will help accelerate the development of a preventive HIV vaccine.

引用

页数：6

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