Cancer-selective apoptotic effects of extracellular and intracellular Par-4

被引：0
作者：
T Shrestha-Bhattarai
V M Rangnekar
机构：
[1] Graduate Center for Toxicology,Department of Radiation Medicine
[2] University of Kentucky,Department of Microbiology
[3] University of Kentucky,undefined
[4] Immunology and Molecular Genetics,undefined
[5] University of Kentucky,undefined
[6] L. P. Markey Cancer Center,undefined
[7] University of Kentucky,undefined
来源：
Oncogene | 2010年 / 29卷
关键词：
Par-4; cell surface GRP78; apoptosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Selectivity toward cancer cells is the most desirable element in cancer therapeutics. Par-4 is a cancer cell-selective proapoptotic protein that functions intracellularly in the cytoplasmic and nuclear compartments as a tumor suppressor. Moreover, recent findings indicate that the Par-4 protein is secreted by cells, and extracellular Par-4 induces cancer cell-specific apoptosis by interaction with the cell-surface receptor GRP78. This review describes the mechanisms underlying the apoptotic effects of both extracellular and intracellular Par-4 acting through its effector domain SAC.
引用
收藏
页码：3873 / 3880
页数：7
相关论文
共 226 条
[1]  
Ahmed MM(2008)Downregulation of PAR-4, a pro-apoptotic gene, in pancreatic tumors harboring K-ras mutation Int J Cancer 122 63-70
[2]  
Sheldon D(1988)Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes Cell 53 549-554
[3]  
Fruitwala MA(1999)Control of apoptosis by Rel/NF-kappaB transcription factors Oncogene 18 6910-6924
[4]  
Venkatasubbarao K(1999)The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression EMBO J 18 6362-6369
[5]  
Lee EY(1997)Immuno-histochemical analysis of the proapoptotic protein Par-4 in normal rat tissues Cell Growth Differ 8 881-890
[6]  
Gupta S(2009)Par-4 is an essential downstream target of DAP-like kinase (Dlk) in Dlk/Par-4-mediated apoptosis Mol Biol Cell 20 4010-4020
[7]  
Almoguera C(1989)ras oncogenes in human cancer: a review Cancer Res 49 4682-4689
[8]  
Shibata D(2009)The tumor suppressor Par-4 activates an extrinsic pathway for apoptosis Cell 138 377-388
[9]  
Forrester K(2001)Par-4 drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression Cancer Res 61 7255-7263
[10]  
Martin J(1999)Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma Oncogene 18 1205-1208
12345678910