miR-126-3p containing exosomes derived from human umbilical cord mesenchymal stem cells promote angiogenesis and attenuate ovarian granulosa cell apoptosis in a preclinical rat model of premature ovarian failure

被引:0
作者
Qingxi Qu
Linghong Liu
Yuqian Cui
Hongli Liu
Jingyang Yi
Weidong Bing
Chunxiao Liu
Detian Jiang
Yanwen Bi
机构
[1] Qilu Hospital of Shandong University,Department of Obstetrics and Gynecology
[2] Shandong University,Research Center of Stem Cell and Regenerative Medicine
[3] Qilu Hospital of Shandong University,Laboratory of Cryomedicine
[4] Christchurch Hospital,Otago Medical School
[5] University of Otago,Department of Cardiovascular Surgery
[6] Qilu Hospital of Shandong University,undefined
来源
Stem Cell Research & Therapy | / 13卷
关键词
Exosomes; Mesenchymal stem cells; Granulosa cell; Angiogenesis; Apoptosis; Premature ovarian insufficiency;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 208 条
[21]  
Hu R(2020)MiR-126-3p inhibits apoptosis and promotes proliferation by targeting phosphatidylinositol 3-kinase regulatory subunit 2 in porcine ovarian granulosa cells Asian Australas J Anim Sci 100 2148-undefined
[22]  
Kalluri R(2016)microRNA-126 targeting PIK3R2 promotes rheumatoid arthritis synovial fibro-blasts proliferation and resistance to apoptosis by regulating PI3K/AKT pathway Exp Mol Pathol 25 6311-undefined
[23]  
LeBleu VS(2021)Exosomes from microRNA-126 overexpressing mesenchymal stem cells promote angiogenesis by targeting the PIK3R2-mediated PI3K/Akt signalling pathway J Cell Mol Med 20 3-undefined
[24]  
Zhao T(2019)Acupuncture reduces apoptosis of granulosa cells in rats with premature ovarian failure via restoring the PI3K/Akt signaling pathway Int J Mol Sci 11 216-undefined
[25]  
Sun F(2020)Small extracellular vesicles derived from embryonic stem cells restore ovarian function of premature ovarian failure through PI3K/AKT signaling pathway Stem Cell Res Ther 9 46-undefined
[26]  
Liu J(2018)Exosomes derived from human adipose mesenchymal stem cells improve ovary function of premature ovarian insufficiency by targeting SMAD Stem Cell Res Ther 10 407-undefined
[27]  
Ding T(2019)Human amnion-derived mesenchymal stem cell (hAD-MSC) transplantation improves ovarian function in rats with premature ovarian insufficiency (POI) at least partly through a paracrine mechanism Stem Cell Res Ther 16 undefined-undefined
[28]  
She J(2019)Human amniotic epithelial cell-derived exosomes restore ovarian function by transferring MicroRNAs against apoptosis Mol Ther Nucleic Acids undefined undefined-undefined
[29]  
Mao F(undefined)undefined undefined undefined undefined-undefined
[30]  
Xu W(undefined)undefined undefined undefined undefined-undefined