T cell suppression as a mechanism for tolerance to MUC1 antigen in MUC1 transgenic mice

被引：0
作者：
Dongshu Chen
Shigeo Koido
Yongqing Li
Sandra Gendler
Jianlin Gong
机构：
[1] Harvard Medical School,Dana
[2] Mayo Clinic Scottsdale,Farber Cancer Institute
来源：
Breast Cancer Research and Treatment | 2000年 / 60卷
关键词：
anti-tumor immunity; MUC1 antigen; T cell suppression; tolerance; transgenic mice;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
C57BL/6 mice transgenic for human MUC1 (MUC1.Tg) have been developed to study immunologic responsiveness to the human MUC1 tumor-associated antigen. In the present studies, MUC1.Tg mice were immunized with purified human MUC1 antigen and irradiated MUC1-positive (MC38/MUC1) tumor cells. Immunization with MUC1 antigen was associated with induction of an anti-MUC1 antibody response and no detectable cytotoxic T cell reactivity. Similar findings were obtained after immunization with irradiated MC38/MUCl tumor cells. The results also demonstrate that immunization of MUC1.Tg mice with MUCl is associated with decreased levels of CD8+ T cells. In addition, expression of αβ T cell receptors and CD28 were down-regulated on CD8+ T cells as a consequence of MUC1 immunization. These findings support a role for T cell suppression in tolerance to MUC1 antigen in MUC1.Tg mice.
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页码：107 / 115
页数：8
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