Extracellular Signal-Regulated Kinase 2 mRNA Expression in the Rat Brain During Aging

被引：0
作者：
Agnes Simonyi
Kevin Murch
Grace Y. Sun
机构：
[1] University of Missouri,Departments of Biochemistry and Interdisciplinary Neuroscience Program
来源：
Neurochemical Research | 2003年 / 28卷
关键词：
Extracellular signal-regulated kinase; mitogen-activated protein kinase; mRNA; aging; hippocampus;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Aging is accompanied by the loss of memory and cognitive functions. The extracellular signal-regulated kinase (ERK) pathway has been shown to play an essential role in synaptic plasticity and memory. Although a reduction in basal ERK1/2 activity has been found in the cerebral cortex in aged rats, changes in ERK1/2 mRNA expression during aging have not been described. In this study, we investigated age differences in the mRNA expression of ERK2 in different brain regions of male Fisher 344 rats (three age-groups) using quantitative in situ hybridization. No age-dependent changes in ERK2 mRNA were detected in the cerebellum or cortical areas. However, in the hippocampus, a 20% decline in mRNA levels was observed in the CA3 region in the 12-month-old group as compared to the 3-month-old group. These results suggest that the impairment in ERK1/2 activity observed during aging is probably not regulated at the gene expression level.
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页码：1375 / 1378
页数：3
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