Gender difference in QTc prolongation of people with mental disorders

被引：2

作者：

Ito H. ^{[1
]}

Kono T. ^{[2
]}

Ishida S. ^{[3
]}

Maeda H. ^{[3
]}

机构：

[1] National Institute of Public Health, Wako, Saitama 351-0197

[2] Department of Psychiatry, Graduate School of Medicine, University of Tokyo, Tokyo

[3] Department of Neuropsychiatry, Kurume University School of Medicine, Kurume

来源：

Annals of General Hospital Psychiatry | / 3卷 / 1期

关键词：

Mental Disorder; Tricyclic Antidepressant; Psychotropic Drug; Droperidol; Thioridazine;

D O I：

10.1186/1475-2832-3-3

中图分类号：

学科分类号：

摘要：

Background: We examined gender difference in QTc interval distribution and its related factors in people with mental disorders. Methods: We retrospectively reviewed medical charts of patients discharged from a university psychiatric unit between November 1997 and December 2000. Subjects were 328 patients (145 males and 183 females) taking psychotropics at their admission. We examined patient characteristics, medical history, diagnosis, and medication before admission. Results: Mean QTc interval was 0.408 (SD = 0.036). QTc intervals in females were significantly longer than those in males. QTc of females without comorbidity was significantly longer than that of males. Conclusion: The influence of gender difference on QTc prolongation in people with mental disorders merits further research. © 2004 Ito et al; licensee BioMed Central Ltd.

引用

页数：6

共 12 条

[1]

Akhtar M., Clinical spectrum of ventricular tachycardia, Circulation, 82, pp. 1561-1573, (1990)

[2]

Moss A.J., Measurement of the QT interval and the risk associated with QTc interval prolongation: A review, Am. J. Cardiol., 72, (1993)

[3]

Makkar R.R., Fromm B.S., Steinman R.T., Meissner M.D., Lehmann M.H., Female gender as a risk factor for torsade de pointes associated with cardiovascular drugs, JAMA, 270, pp. 2590-2597, (1993)

[4]

Collins P., Stevenson J.C., Mosca L., Spotlight on gender, Cardiovasc. Res., 53, pp. 535-537, (2002)

[5]

Yap Y.G., Risk of torsades de pointes with non-cardiac drugs: Doctors need to be aware that many drugs can cause QT prolongation, BMJ, 430, pp. 1158-1159, (2000)

[6]

Glassman A.H., Bigger J.T., Antipsychotic drugs: Prolonged QTc interval, torsade de pointes, and sudden death, Am. J. Psychiatry, 158, pp. 1774-1782, (2001)

[7]

Hennessy S., Bilker W.B., Knauss J.S., Margolis D.J., Kimmel S.E., Reynolds R.F., Glasser D.B., Morrison M.F., Strom B.L., Cardiac arrest and ventricular arrhythmia in patients taking antipsychotic drugs: Cohort study using administrative data, BMJ, 325, pp. 1070-1072, (2002)

[8]

Mehtonen O.P., Aranko K., Malkonen L., Vapaatalo H., A study of sudden death associated with the use of antipsychotic or antidepressant drugs: 49 cases in Finland, Acta Psychiatr. Scand., 84, pp. 58-64, (1991)

[9]

Ray W.A., Meredith S., Thapa P.B., Meador K.G., Hall K., Murray K.T., Antipsychotics and the risk of sudden cardiac death, Arch. Gen. Psychiatry, 58, pp. 1161-1167, (2001)

[10]

Reilly J.G., Ayis S.A., Ferrier I.N., Jones S.J., Thomas S.H.I., QTc-interval abnormalities and psychotropic drug therapy in psychiatric patients, Lancet, 355, pp. 1048-1052, (2000)

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