Smoking affects symptom improvement in schizophrenia: a prospective longitudinal study of male patients with first-episode schizophrenia

被引：4

作者：

Mu, Xishu ^{[1
]}

Wu, Wenjing ^{[2
]}

Wang, Sisi ^{[2
]}

Su, Xiuru ^{[1
]}

Guan, Hengyong ^{[1
]}

Guan, Xiaoni ^{[3
]}

Lu, Xiaobing ^{[4
,5
,6
,7
]}

Li, Zezhi ^{[4
,5
,6
,7
]}

机构：

[1] Hebei Prov Vet Hosp, Baoding, Peoples R China

[2] Qingdao Mental Hlth Ctr, Qingdao, Peoples R China

[3] Peking Univ, Beijing HuiLongGuan Hosp, HuiLongGuan Clin Med Sch, Beijing, Peoples R China

[4] Guangzhou Med Univ, Affiliated Brain Hosp, Dept Nutr & Metab Psychiat, Guangzhou, Peoples R China

[5] Guangdong Engn Technol Res Ctr Translat Med Mental, Guangzhou, Peoples R China

[6] Guangzhou Med Univ, Key Lab Neurogenet & Channelopathies Guangdong Pro, Guangzhou, Peoples R China

[7] Guangzhou Med Univ, Minist Educ China, Guangzhou, Peoples R China

来源：

SCHIZOPHRENIA | 2024年 / 10卷 / 01期

关键词：

CIGARETTE-SMOKING; NEGATIVE SYMPTOMS; NICOTINE DEPENDENCE; TOBACCO SMOKING; DOPAMINE; METAANALYSIS; ASSOCIATION; HYPOTHESIS; RECEPTORS; COGNITION;

D O I：

10.1038/s41537-024-00449-1

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Patients with schizophrenia (SCZ) smoke up to three times more than general people. However, there are conflicting results regarding the relationship between tobacco smoke and clinical symptom severity in SCZ. The aim of this study was to assess the impact of smoking on clinical symptoms after antipsychotic treatment in a 12-week cohort study after controlling for confounding factors. One hundred and forty-five male patients with drug-na & iuml;ve first-episode (DNFE) SCZ received antipsychotic monotherapy for 12 weeks. Symptom severity was assessed at baseline and at week 12 by the Positive and Negative Syndrome Scale (PANSS). We found no differences in clinical symptoms among male smokers with SCZ compared with male nonsmokers. However, male smokers showed greater improvement in negative symptoms after 12 weeks of treatment, controlling for age, years of education, onset age, and baseline body mass index (BMI). Our study showed that after 12 weeks of treatment with antipsychotics, male smokers showed greater improvement in negative symptoms than male nonsmokers.

引用

页数：5

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