SRGN amplifies microglia-mediated neuroinflammation and exacerbates ischemic brain injury

被引：0
作者：
Yi Qian
Lixuan Yang
Jian Chen
Chao Zhou
Ningning Zong
Yang Geng
Shengnan Xia
Haiyan Yang
Xinyu Bao
Yan Chen
Yun Xu
机构：
[1] Nanjing Drum Tower Hospital,Department of Neurology
[2] Affiliated Hospital of Medical School,Department of Neurology
[3] Nanjing University,Jiangsu Key Laboratory for Molecular Medicine
[4] Nanjing Drum Tower Hospital,undefined
[5] State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases,undefined
[6] Nanjing University,undefined
[7] Medical School of Nanjing University,undefined
[8] Jiangsu Provincial Key Discipline of Neurology,undefined
[9] Nanjing Neurology Medical Center,undefined
来源：
Journal of Neuroinflammation | / 21卷
关键词：
Ischemic stroke; Neuroinflammation; Microglia; Serglycin; CD44;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [41] 6-Gingerol attenuates microglia-mediated neuroinflammation and ischemic brain injuries through Akt-mTOR-STAT3 signaling pathway
    Liu, Ying
    Deng, ShiJi
    Zhang, Zhi
    Gu, Yue
    Xia, ShengNan
    Bao, XinYu
    Cao, Xiang
    Xu, Yun
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2020, 883
  • [42] Downregulation of High mobility group box 2 relieves spinal cord injury by inhibiting microglia-mediated neuroinflammation
    Yang, Pengzhi
    He, Jie
    Wang, Changlin
    Yang, Chi
    Jian, Fengzeng
    EXPERIMENTAL ANIMALS, 2023, 72 (02) : 199 - 208
  • [43] The Neuroprotective Mechanisms of PPAR-γ: Inhibition of Microglia-Mediated Neuroinflammation and Oxidative Stress in a Neonatal Mouse Model of Hypoxic-Ischemic White Matter Injury
    Fang, Mingchu
    Yu, Qianqian
    Ou, Jiahao
    Lou, Jia
    Zhu, Jianghu
    Lin, Zhenlang
    CNS NEUROSCIENCE & THERAPEUTICS, 2024, 30 (11)
  • [44] Deregulated miR-384 serves as a biomarker in neonatal hypoxic-ischemic encephalopathy and alleviates microglia-mediated neuroinflammation
    Zhang, Guangyun
    Ye, Mei
    Li, Min
    MOLECULAR BIOLOGY REPORTS, 2020, 47 (07) : 5411 - 5420
  • [45] Deregulated miR-384 serves as a biomarker in neonatal hypoxic-ischemic encephalopathy and alleviates microglia-mediated neuroinflammation
    Guangyun Zhang
    Mei Ye
    Min Li
    Molecular Biology Reports, 2020, 47 : 5411 - 5420
  • [46] ADAR1 Promotes NUPR1 A-to-I RNA Editing to Exacerbate Ischemic Brain Injury by Microglia Mediated Neuroinflammation
    Wang, Guo-Ping
    Li, Wen-Juan
    Li, Ye
    Ma, Ming-Xing
    Guo, Kai-Kai
    NEUROMOLECULAR MEDICINE, 2025, 27 (01)
  • [47] Circadian rhythm, microglia-mediated neuroinflammation, and Alzheimer's disease
    Geng, Fan
    Zhao, Na
    Ren, Qingguo
    NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2025, 170
  • [48] Ferulic acid attenuates microglia-mediated neuroinflammation in retinal degeneration
    Sun, Xiaowei
    Sun, Peng
    Liu, Limei
    Jiang, Pengfei
    Li, Yuanbin
    BMC OPHTHALMOLOGY, 2021, 21 (01)
  • [49] Neuroinflammation in Ischemic Stroke: Focus on MicroRNA-mediated Polarization of Microglia
    Lian, Lu
    Zhang, Yunsha
    Liu, Lu
    Yang, Liji
    Cai, Yichen
    Zhang, Junping
    Xu, Shixin
    FRONTIERS IN MOLECULAR NEUROSCIENCE, 2021, 13
  • [50] Ferulic acid attenuates microglia-mediated neuroinflammation in retinal degeneration
    Xiaowei Sun
    Peng Sun
    Limei Liu
    Pengfei Jiang
    Yuanbin Li
    BMC Ophthalmology, 21
12345