The praziquantel in preschoolers (PIP) trial: study protocol for a phase II PK/PD-driven randomised controlled trial of praziquantel in children under 4 years of age

[1] Colley DG(2018)Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017 Lancet. 392 1859-1922

[2] Bustinduy AL(2014)Human schistosomiasis Lancet. 383 2253-2264

[3] Secor WE(2017)Paediatric and maternal schistosomiasis: shifting the paradigms Br Med Bull 123 115-125

[4] King CH(2013)Impact of polyparasitic infections on anemia and undernutrition among Kenyan children living in a Schistosoma haematobium-endemic area Am J Trop Med Hyg 88 433-440

[5] Bustinduy AL(2005)Human schistosomiasis and anemia: the relationship and potential mechanisms Trends Parasitol 21 386-392

[6] Stothard JR(2018)Cognitive deficits and educational loss in children with schistosome infection-A systematic review and meta-analysis PLoS Negl Trop Dis 12 e0005524-1506

[7] Friedman JF(2019)Schistosoma mansoni Infection as a Predictor of Low Aerobic Capacity in Ugandan Children Am J Trop Med Hyg 100 1498-454

[8] Bustinduy AL(2009)Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993-2005 Public Health Nutr 12 444-1606

[9] Parraga IM(2011)Closing the praziquantel treatment gap: new steps in epidemiological monitoring and control of schistosomiasis in African infants and preschool-aged children Parasitology. 138 1593-544

[10] Thomas CL(2015)Changing policy and practice in the control of pediatric schistosomiasis Pediatrics. 135 536-205

[1] Colley DG(2018)Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017 Lancet. 392 1859-1922

[2] Bustinduy AL(2014)Human schistosomiasis Lancet. 383 2253-2264

[3] Secor WE(2017)Paediatric and maternal schistosomiasis: shifting the paradigms Br Med Bull 123 115-125

[4] King CH(2013)Impact of polyparasitic infections on anemia and undernutrition among Kenyan children living in a Schistosoma haematobium-endemic area Am J Trop Med Hyg 88 433-440

[5] Bustinduy AL(2005)Human schistosomiasis and anemia: the relationship and potential mechanisms Trends Parasitol 21 386-392

[6] Stothard JR(2018)Cognitive deficits and educational loss in children with schistosome infection-A systematic review and meta-analysis PLoS Negl Trop Dis 12 e0005524-1506

[7] Friedman JF(2019)Schistosoma mansoni Infection as a Predictor of Low Aerobic Capacity in Ugandan Children Am J Trop Med Hyg 100 1498-454

[8] Bustinduy AL(2009)Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993-2005 Public Health Nutr 12 444-1606

[9] Parraga IM(2011)Closing the praziquantel treatment gap: new steps in epidemiological monitoring and control of schistosomiasis in African infants and preschool-aged children Parasitology. 138 1593-544

[10] Thomas CL(2015)Changing policy and practice in the control of pediatric schistosomiasis Pediatrics. 135 536-205