Structure versus function: Correlation between outer retinal and choroidal thicknesses measured by swept-source OCT with multifocal electroretinography and visual acuity

被引：4

作者：

Flores-Moreno I. ^{[1
,2
]}

Arias-Barquet L. ^{[1
]}

Rubio-Caso M.J. ^{[1
]}

Muñoz-Blanco A. ^{[1
]}

Vidal-Martí M. ^{[1
]}

Catala-Mora J. ^{[1
]}

Ruiz-Moreno J.M. ^{[3
]}

Duker J.S. ^{[4
]}

Caminal J.M. ^{[1
]}

机构：

[1] Department of Ophthalmology, Bellvitge University Hospital, L'Hospitalet de Llobregat, Feixa Llarga, s/n, Barcelona

[2] Department of Ophthalmology, Clínico San Carlos University Hospital, Madrid

[3] Department of Ophthalmology, Castilla La Mancha University, Albacete

[4] New England Eye Center, Tufts Medical Center, Boston, MA

来源：

International Journal of Retina and Vitreous | / 3卷 / 1期

关键词：

Choroidal thickness; Multifocal electroretinography; OCT; Swept-source; Visual acuity;

D O I：

10.1186/s40942-017-0082-y

中图分类号：

学科分类号：

摘要：

Background: To correlate retina-choroidal anatomy as assessed via swept-source OCT (SS-OCT) with retinal function as determined by best-corrected visual acuity (BCVA) and multifocal electroretinogram (mfERG). Methods: Thirty-three eyes from 33 patients including 16 with neovascular AMD (nvAMD) and 17 controls were included. Patients were included in the present study after a complete ophthalmologic examination, including BCVA, slit-lamp study, intraocular pressure measurement, dilated fundus examination after tropicamide instillation, SD-OCT, SS-OCT, fundus photographs and mfERG. Age, sex, BCVA, number of anti-VEGF intravitreal injections in the nvAMD group, were recollected. Outer retinal and choroidal thickness were determined at the fovea and 500 μm temporal, superior, nasal and inferior. First-order response from mfERG was collected. P1 amplitude was recorded in R1, R2 and the average of R1 + R2. The measurements recollected from the SS-OCT, mfERG and BCVA were compared. Results: Better BCVA was found with thicker outer retina foveal thickness (r = 0.349; P = 0.047), with thicker subfoveal choroidal thickness (r = 0.443; P = 0.010), and with higher amplitude in P1 at R1 (r = 0.346; P = 0.037). Outer retina foveal thickness did not correlate with P1 amplitude at R1 (r = 0.072; P = 0.692), R2 (r = 0.265; P = 0.137) either with the average P1 amplitude at R1 + R2 (r = 0.253; P = 0.156). A thicker subfoveal choroidal thickness was related with higher amplitude in P1 at R1 (r = 0.383; P = 0.028), R2 (r = 0.409; P = 0.018) and the average of R1 + R2 (r = 0.419; P = 0.015). Conclusions: Choroidal thickness demonstrated a positive correlation with retinal function in the sample studied, so a thicker choroid is related to a better retinal function measured with mfERG and BCVA.. © The Author(s) 2017.

引用

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