Association of DISC1 Polymorphisms with Late-Onset Alzheimer’s Disease in Northern Han Chinese

被引：0
作者：
Xiao-Yan Zhang
Hui-Fu Wang
Meng-Shan Tan
Yu Wan
Ling-Li Kong
Zhan-Jie Zheng
Chen-Chen Tan
Wei Zhang
Zi-Xuan Wang
Lin Tan
Teng Jiang
Lan Tan
Jin-Tai Yu
机构：
[1] Qingdao University,Department of Neurology, Qingdao Municipal Hospital, School of Medicine
[2] Nanjing Medical University,Department of Neurology, Qingdao Municipal Hospital
[3] Qingdao Mental Health Center,Department of Geriatric
[4] Qingdao University,Department of Emergency, Qingdao Municipal Hospital, School of Medicine
[5] Ocean University of China,College of Medicine and Pharmaceutics
[6] Nanjing Medical University,Department of Neurology, Nanjing First Hospital
[7] University of California,Memory and Aging Center, Department of Neurology
来源：
Molecular Neurobiology | 2017年 / 54卷
关键词：
Alzheimer’s disease; Polymorphism; Association;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The disrupted-in-schizophrenia-1 (DISC1) is a candidate gene for psychiatric diseases and plays various roles in brain development. It has been reported as a candidate gene for Alzheimer's disease (AD) in a recent large genome-wide association study in Caucasians. To explore the associations between DISC1 and AD, we performed a case–control study including 2318 subjects in Northern Han Chinese. We found that one single nucleotide polymorphism (rs6675281) was associated with the risk of late-onset Alzheimer’s disease (LOAD) in northern Han Chinese population. As for rs821616 and rs3738401, no association was detected with LOAD. In conclusion, DISC1 increased the risk for LOAD in northern Han Chinese population.
引用
收藏
页码：2922 / 2927
页数：5
相关论文
共 219 条
[1]  
Tan L(2013)Association of GWAS-linked loci with late-onset Alzheimer’s disease in a northern Han Chinese population Alzheimers Dement 9 546-553
[2]  
Yu JT(2013)NLRP3 polymorphisms are associated with late-onset Alzheimer’s disease in Han Chinese J Neuroimmunol 265 91-95
[3]  
Zhang W(2013)TREM2 variants in Alzheimer’s disease N Engl J Med 368 117-127
[4]  
Wu ZC(2013)Bridging integrator 1 (BIN1): form, function, and Alzheimer’s disease Trends Mol Med 19 594-603
[5]  
Zhang Q(2014)Association of LRRTM3 polymorphisms with late-onset Alzheimer’s disease in Han Chinese Exp Gerontol 52 18-22
[6]  
Liu QY(2014)Genetic variation in BIN1 gene and Alzheimer’s disease risk in Han Chinese individuals Neurobiol Aging 35 1781 e1781-e1788
[7]  
Wang W(2014)Genetic variation in PICALM and Alzheimer’s disease risk in Han Chinese Neurobiol Aging 35 934 e931-933
[8]  
Wang HF(2009)Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease Am J Hum Genet 84 35-43
[9]  
Ma XY(2014)No evidence of DISC1-associated morphological changes in the hippocampus, anterior cingulate cortex, or striatum in major depressive disorder cases and healthy controls J Affect Disord 166 103-107
[10]  
Cui WZ(2011)Common DISC1 polymorphisms disrupt Wnt/GSK3beta signaling and brain development Neuron 72 545-558
12345678910