Structural snapshots of the reaction coordinate for O-GlcNAc transferase

被引：0
|
作者：
Michael B Lazarus
Jiaoyang Jiang
Tracey M Gloster
Wesley F Zandberg
Garrett E Whitworth
David J Vocadlo
Suzanne Walker
机构：
[1] Harvard University,Department of Chemistry and Chemical Biology
[2] Harvard Medical School,Department of Microbiology and Immunobiology
[3] Simon Fraser University,Department of Chemistry
[4] Simon Fraser University,Department of Molecular Biology and Biochemistry
来源：
Nature Chemical Biology | 2012年 / 8卷
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摘要：
Understanding the reaction mechanism of OGT, responsible for O-GlcNAcylating various protein substrates, has been hampered by a lack of structural information. Snapshots of ternary complexes along the reaction coordinate now provide evidence for substrate participation in an electrophilic migration mechanism.[graphic not available: see fulltext]
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页码：966 / 968
页数：2
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