Clinical and Metabolic Responses to Magnesium Supplementation in Women with Polycystic Ovary Syndrome

被引：0
作者：
Maryam Farsinejad-Marj
Leila Azadbakht
Farahnaz Mardanian
Parvane Saneei
Ahmad Esmaillzadeh
机构：
[1] Isfahan University of Medical Sciences,Food Security Research Center
[2] Isfahan University of Medical Sciences,Students’ Research Committee
[3] Isfahan University of Medical Sciences,Department of Community Nutrition, School of Nutrition and Food Science
[4] Tehran University of Medical Sciences,Department of Community Nutrition, School of Nutritional Sciences and Dietetics
[5] Tehran University of Medical Sciences,Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular
[6] Isfahan University of Medical Sciences, Cellular Sciences Institute
来源：
Biological Trace Element Research | 2020年 / 196卷
关键词：
Magnesium; Supplementation; PCOS; Sex hormones; Metabolic profiles; Insulin;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We hypothesized that magnesium supplementation might help improve metabolic profiles and clinical symptoms of polycystic ovary syndrome (PCOS) through its role in insulin action. The present study aimed to investigate the effect of magnesium supplementation on metabolic profiles and levels of sex hormones in women with PCOS. In this parallel randomized, double-blind, placebo-controlled clinical trial, 60 women with PCOS aged 20–45 years were recruited. After stratification for body mass index (BMI), age, and types of medications, participants were randomly assigned to consume magnesium supplements (containing 250 mg magnesium oxide) or placebo for 8 weeks. To assess biochemical indicators, a venous blood sample was taken after an overnight fasting. The mean age of study participants was 26.4 years. We found that magnesium supplementation for 8 weeks among women with PCOS had favorable effects on BMI compared with the placebo group (changes from baseline in intervention group: − 0.31 ± 0.07 vs. 0.07 ± 0.09 kg/m2 in control group). In addition, the supplementation lead to preventing the increase in waist circumference in intervention group compared with the control group (0.02 vs. 1.15 cm). No significant effects on glycemic variables and lipid profile were seen following the magnesium supplementation. A significant increase in serum LH levels in intervention group and a decrease in placebo group were observed (P = 0.01). Although we found a significant decrease in serum testosterone levels in intervention and placebo groups, comparing the changes between the two groups, a marginally significant difference in serum testosterone levels was found (51.65 vs. 47.80 in intervention, 43.41 vs. 39.46 in placebo, P = 0.08). A significant increase in serum dehydroepiandrogens (DHEA) (136.32 vs. 172.37 intervention, 102.74 vs. 120.15 placebo, P = 0.01) was seen in two groups. Magnesium supplementation had no significant effects on FSH, 17OH-progesteron, sex hormone–binding globulin (SHBG), and free androgen index (FAI) levels. We found evidence indicating that magnesium supplementation did not influence serum lipid profiles and glycemic indicators among women with PCOS. Magnesium supplementation resulted in reduced BMI and testosterone levels as well as increased DHEA concentrations in women with PCOS. Also, magnesium supplementation may increase serum LH levels. ClinicalTrials.gov IRCT registration no. NCT02178150
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页码：349 / 358
页数：9
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