Brief Report: Platelet-Poor Plasma Serotonin in Autism

被引：0
作者：
George M. Anderson
Margaret E. Hertzig
P. A. McBride
机构：
[1] Yale University School of Medicine,Departments of Child Psychiatry & Laboratory Medicine
[2] Cornell University Medical College,Department of Psychiatry
来源：
Journal of Autism and Developmental Disorders | 2012年 / 42卷
关键词：
Autism; Serotonin; Hyperserotonemia; Platelet; Platelet-poor plasma (PPP);
D O I：
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中图分类号：
学科分类号：
摘要：
Possible explanations for the well-replicated platelet hyperserotonemia of autism include an alteration in the platelet’s handling of serotonin (5-hydroxyserotonin, 5-HT) or an increased exposure of the platelet to 5-HT. Measurement of platelet-poor plasma (PPP) levels of 5-HT appears to provide the best available index of in vivo exposure of the platelet to 5-HT. Mean (±SD) concentrations of PPP 5-HT observed in the autism (N = 18), hyperserotonemic subgroup (N = 5) and control (N = 24) groups were 0.86 ± 0.53, 0.87 ± 0.43 and 0.86 ± 0.36 nM, respectively. The results suggest that the hyperserotonemia of autism is not due to increased exposure of the platelet to 5-HT and make it more likely that the factor(s) contributing to the hyperserotonemia of autism have to do with the platelet’s handling of 5-HT.
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页码：1510 / 1514
页数：4
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