Conformational dynamics in substrate-binding domains influences transport in the ABC importer GlnPQ

被引：0
作者：
Giorgos Gouridis
Gea K Schuurman-Wolters
Evelyn Ploetz
Florence Husada
Ruslan Vietrov
Marijn de Boer
Thorben Cordes
Bert Poolman
机构：
[1] Groningen Biomolecular Sciences and Biotechnology Institute,Department of Biochemistry
[2] University of Groningen,undefined
[3] Molecular Microscopy Research Group,undefined
[4] Zernike Institute for Advanced Materials,undefined
[5] University of Groningen,undefined
来源：
Nature Structural & Molecular Biology | 2015年 / 22卷
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摘要：
Bacterial ABC importer GlnPQ has two fused substrate-binding domains (SBDs). Single-molecule FRET is now used to probe the conformational dynamics of the SBDs, which are shown to directly influence transport rates.
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页码：57 / 64
页数：7
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