Nitric Oxide and Antioxidant Defense in Patients with Gastric Cancer

被引：0

作者：

Yildiz Dincer

Tülay Akcay

Osman B. Tortum

Gülen Dogusoy

机构：

[1] Istanbul University,Department of Biochemistry, Cerrahpasa Medical Faculty

[2] Istanbul University,Department of General Surgery, Cerrahpasa Medical Faculty

[3] Istanbul University,Department of Pathology, Cerrahpasa Medical Faculty

[4] Dere Sok.,undefined

[5] Umut Ap. No. 21/44 Sahrayi Cedid,undefined

[6] Erenkoy,undefined

来源：

Digestive Diseases and Sciences | 2006年 / 51卷

关键词：

Gastric cancer; Nitric oxide; Superoxide dismutase; Glutathione peroxidase;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

In the present study, total nitrate and nitrite level (as end product of nitric oxide), superoxide dismutase activity, and glutathione peroxidase activity in leukocytes were determined in patients with gastric cancer, and the relationship between measured parameters and tumor grade were evaluated. Leukocyte nitrate and nitrite level was found to be increased and superoxide dismutase activity was found to be decreased in patients compared to controls. When the patient group was categorized, nitrate and nitrite level was found to be higher in patients with a high-grade tumor than in patients with a grade I tumor. We concluded that an increased level of leukocyte nitrate and nitrite is related to tumor grade in patients with gastric cancer; antioxidant activity is also impaired in these patients but it does not seem to be related to grade of tumor.

引用

页码：1367 / 1370

页数：3

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