Nonsteroidal anti-inflammatory drug-induced gastrointestinal toxicity: New insights into an old problem

被引：0
作者：
Neal M. Davies
John L. Wallace
机构：
[1] University of Calgary,Intestinal Disease Research Unit, Faculty of Medicine
来源：
Journal of Gastroenterology | 1997年 / 32卷
关键词：
non-steroidal anti-inflammatory drugs; gastrointestinal; cyclooxygenase; nitric oxide; prostaglandins;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Nonsteroidal anti-inflammatory drugs are widely used for the treatment of chronic arthropathies, but their gastrointestinal damage remains a significant limitation to their use. In this review, the pathogenic mechanisms through which these drugs are believed to cause gastrointestinal damage are outlined. A better understanding of the pathogenesis of gastric and intestinal injury has resulted in novel strategies that are being employed to develop nonsteroidal anti-inflammatory drugs that do not have significant adverse effects on the gastrointestinal tract.
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页码：127 / 133
页数：6
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