Analysis of the possible involvement of the glutamate transporter gene EAAT2 and the glutamate receptor genes GRIA1 and GRIA2 in the pathogenesis of motor neuron disease in the Russian population

被引：0
作者：
A. L. Zherebtsova
M. I. Shadrina
E. V. Semenova
G. N. Levitsky
A. V. Alekhin
P. A. Slominsky
V. I. Skvortsova
S. A. Limborska
机构：
[1] Russian Academy of Sciences,Institute of Molecular Genetics
[2] Russian State Medical University,undefined
来源：
Russian Journal of Genetics | 2006年 / 42卷
关键词：
Glutamate; Motor Neuron; Receptor Gene; Glutamate Receptor; Transporter Gene;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Polymorphisms of the genes of the glutamatergic system EAAT2, GRIA1, and GRIA2 have been analyzed in patients with sporadic motor neuron disease (MND) from Russia. The disease is not associated with polymorphic alleles of the genes studied, which indicates that EAAT2, GRIA1, and GRIA2 play an insignificant role in the pathogenesis of sporadic MND.
引用
收藏
页码：89 / 93
页数：4
相关论文
共 57 条
[1]  
Skvortsova V.(2004)Analysis of Heavy Neurofilament Subunit Gene Polymorphism in Russian Patients with Sporadic Motor Neuron Disease (MND) Eur. J. Hum. Genet. 12 241-244
[2]  
Shadrina M.(2004)Analysis of the Glutathione S-Transferase P1 Gene Ile105Val Polymorphism in the Patients with Sporadic Motor Neuron Disease from Russia Rus. J. Genet. 40 691-693
[3]  
Slominsky P.(2003)Analysis of the Ala9Val Polymorphism of the MnContaining Superdismutase Gene in Patients with Sporadic Motor Neuron Disease from Russia Med. Genet. 2 442-444
[4]  
Zherebtsova A.L.(2002)Polymorphism of Glutathione S-Transferase Genes M1 and T1 in Patients with Motor Neuron Disease from the Moscow Population Rus. J. Genet. 38 1327-1329
[5]  
Shadrina M.I.(2004)Sporadic Amyotriphic Lateral Sclerosis: Analysis of Genetic Risk Factors in the Russian Population Med. Genet. 3 513-520
[6]  
Levitsky G.N.(2001)Sporadic ALS Associated with the D90A Cu,Zn Superoxide Dismutase Mutation in Russia Eur. J. Neurol. 8 167-172
[7]  
Kondratyeva E.A.(1999)Amyotrophic Lateral Sclerosis Zh. Nevrol. Psikhiatr. 99 60-64
[8]  
Shadrina M.I.(1993)Chromosomal Localization of Glutamate Receptor Genes: Relationship to Familial Amyotrophic Lateral Sclerosis and Other Neurological Disorders of Mice and Humans Proc. Natl. Acad. Sci. USA: Neurobiology 90 3053-3057
[9]  
Levitsky G.N.(2000)The Role of Excitotoxicity in ALS—What Is the Evidence? J. Neurol. 247 7-16
[10]  
Shadrina M.I.(2003)Interactions between Glutamate Transporters and Metabotropic Glutamate Receptors at Excitatory Synapses in the Cerebellar Cortex Neurochem. Int. 45 537-544
123456