Biotechnological production of enantiomeric pure lactic acid from renewable resources: recent achievements, perspectives, and limits

被引：0
作者：
Kenji Okano
Tsutomu Tanaka
Chiaki Ogino
Hideki Fukuda
Akihiko Kondo
机构：
[1] Kobe University,Department of Molecular Science and Material Engineering, Graduate School of Science and Technology
[2] Kobe University,Organization of Advanced Science and Technology
[3] Kobe University,Department of Chemical Science and Engineering, Graduate School of Engineering
来源：
Applied Microbiology and Biotechnology | 2010年 / 85卷
关键词：
Lactic acid fermentation; Lactic acid bacteria; Yeast; Optically pure lactic acid;
D O I：
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中图分类号：
学科分类号：
摘要：
Lactic acid (LA) is an important and versatile chemical that can be produced from renewable resources such as biomass. LA is used in the food, pharmaceutical, and polymers industries and is produced by microorganism fermentation; however, most microorganisms cannot directly utilize biomass such as starchy materials and cellulose. Here, we summarize LA production using several kinds of genetically modified microorganisms, such as LA bacteria, Escherichia coli, Corynebacterium glutamicum, and yeast. Using gene manipulation and metabolic engineering, the yield and optical purity of LA produced from biomass has been significantly improved. In this review, the drawbacks as well as improvements of LA production by fermentation is discussed.
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页码：413 / 423
页数：10
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