Protective Effect of Juglans regia L. Walnut Extract Against Oxidative DNA Damage

被引：0
|
作者：
Cinzia Calcabrini
Roberta De Bellis
Umberto Mancini
Luigi Cucchiarini
Vilberto Stocchi
Lucia Potenza
机构：
[1] University of Urbino Carlo Bo,Department of Biomolecular Sciences
[2] Alma Mater Studiorum-University of Bologna,Department for Life Quality Studies
来源：
Plant Foods for Human Nutrition | 2017年 / 72卷
关键词：
L.; Keratinocytes; Oxidative stress; DNA damage;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Walnuts (Juglans regia L.) are relevant components of the Mediterranean diet providing important macronutrients, micronutrients and other bioactive constituents including unsaturated fatty acids, proteins, fiber, vitamins, minerals, phytosterols and polyphenols. Although the walnut beneficial effects in human health are widely recognized by a lot of epidemiologic studies very little is known regarding its effect on damaged DNA. The aim of the present study was to investigate the effect of Juglans regia L. ethanolic extract from kernel on the induction of DNA strand breaks by thiol/Fe3+/O2 mixed function oxidase, tert-butyl hydroperoxide or UVC radiations in acellular and cellular models. Plasmid DNA cleavage and fast Halo assay were used to monitor oxidative damage to DNA. Both approaches showed protection of oxidatively injured DNA. These results agree with a lot of scientific proofs which recommend walnut as dietary adjunct in health promotion and prevention as well as in treatment of lifestyle-related oxidative diseases.
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页码：192 / 197
页数：5
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