Cystic and Non-Cystic Fibrosis Pseudomonas aeruginosa Isolates are not Differentiated by the Quorum-Sensing Signaling and Biofilm Production

被引：0
作者：
Leandro Reus Rodrigues Perez
Ana Lúcia Peixoto de Freitas
Afonso Luís Barth
机构：
[1] UFRGS,Pharmaceutical Sciences, Faculdade de Farmácia
[2] UFRGS,Clinical Analysis Department, Faculdade de Farmácia
[3] Hospital de Clínicas de Porto Alegre,Microbiology Unit, Clinical Pathology Service
来源：
Current Microbiology | 2012年 / 64卷
关键词：
Cystic Fibrosis; Cystic Fibrosis Patient; Violacein; Cystic Fibrosis Lung; Chromobacterium Violaceum;
D O I：
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学科分类号：
摘要：
The capability for biofilm and quorum-sensing (QS) signaling production among Pseudomonas aeruginosa isolates were evaluated. A total of 231 isolates were recovered from sputa of cystic fibrosis (CF, n = 104) and non-CF (non-CF, n = 127) patients. One hundred ninety-seven (85.3%; 95% CI 80.1–89.3%) were biofilm producers and 157 (68%; 95% CI 61.7–73.6%) were weak QS-producing. No difference was observed between CF and non-CF isolates regarding the ability to produce biofilm and QS-signaling. Interestingly, the degree of QS production appears to be related to the degree of biofilm production. Thus, blocking QS pathways may be crucial in the prevention and treatment of biofilm-related infections.
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页码：81 / 84
页数：3
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