Risk of cancer in patients with sleep apnea: comparison of surgery versus CPAP in a long-term follow-up study

被引：2

作者：

O'Connor-Reina, Carlos ^{[1
,2
]}

Alcala, Laura Rodriguez ^{[1
,2
]}

Ignacio, Jose Maria ^{[3
]}

Garcia-Iriarte, Maria Teresa ^{[4
]}

Llatas, Marina Carrasco ^{[5
]}

Morente, Juan Carlos Casado ^{[1
]}

del Rey, David Perez ^{[6
]}

Hilara, Alba Segovia ^{[6
]}

Ibarburu, Gema Hernandez ^{[7
]}

Baptista, Peter ^{[8
]}

Plaza, Guillermo ^{[9
,10
]}

机构：

[1] Hosp Quironsalud Marbella, Otorhinolaryngol Dept, Marbella 29680, Spain

[2] Hosp Quironsalud Campo Gibraltar, Otorhinolaryngol Dept, Palmones, Spain

[3] Hosp Quironsalud Marbella, Neumol Dept, Marbella, Spain

[4] Hosp Univ Virgen Valme, Otorhinolaryngol Dept, Seville, Spain

[5] Otorhinolaryngol Dept Hosp Univ Dr Peset, Valencia, Spain

[6] Univ Politecn Madrid, Biomed Informat Grp, Madrid, Spain

[7] TriNetX Europe NV, Sint Martens Latem, Belgium

[8] Otorhinolaryngol Dept, Clin Univ Navarra, Pamplona, Spain

[9] Univ Rey Juan Carlos, Hosp Univ Fuenlabrada, Otorhinolaryngol Dept, Madrid 28042, Spain

[10] Hosp Sanitas Zarzuela, Otorhinolaryngol Dept, Madrid, Spain

来源：

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY | 2024年 / 281卷 / 06期

关键词：

Sleep apnea; Upper airway surgery; Continuous positive airway pressure (CPAP); Big data; Survival; Cancer; MORTALITY;

D O I：

10.1007/s00405-023-08446-3

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

PurposeThis study aimed to obtain a comprehensive view of the risk of developing cancer in patients with obstructive sleep apnea (OSA) and to compare this risk between patients receiving continuous positive airway pressure (CPAP) therapy versus upper airway surgery (UAS).MethodsWe used both local data and a global-scale federated data research network, TriNetX, to access electronic medical records, including those of patients diagnosed with OSA from health-care organizations (HCOs) worldwide. We used propensity score matching and the score-matched analyses of data for 5 years of follow-up,ResultsWe found that patients who had undergone UAS had a similar risk of developing cancer than those who used CPAP [hazard ratio of 0.767 (95% CI 0.559-1.053; P = 0.100)].ConclusionAnalysis of the large data sets collected from HCOs in Europe and globally lead us to conclude that in patients with OSA, neither CPAP nor UAS were associated with the development of cancer better than in non-treated patients.

引用

页码：3131 / 3141

页数：11

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