Molecular variation within the dopamine receptor DRD2 gene in migraine

被引：0

作者：

Stephen J. Peroutka

机构：

[1] iO Pharmaceuticals,

[2] 601 Gateway Boulevard,undefined

[3] Suite 460,undefined

[4] South San Francisco,undefined

[5] CA 94080,undefined

[6] USA,undefined

[7] Tel.: +1-650-574-2246,undefined

[8] Fax: +1-650-571-6433,undefined

来源：

The Journal of Headache and Pain | 2000年 / 1卷 / Suppl 2期

关键词：

Key words Dopamine; Migraine; Genetics; DRD2;

D O I：

10.1007/s101940070009

中图分类号：

学科分类号：

摘要：

Molecular genetics offers a novel approach to the understanding and management of migraine since the disorder is known to have a strong genetic component. In recent studies, polymorphisms in the genes for dopamine receptors have been evaluated. Both positive and negative association studies have been reported. In particular, these data suggest that activation of the DRD2 receptor plays a modifying role in the pathophysiology of migraine. As a result, existing data provide a molecular rationale for the documented efficacy of dopamine D2 receptor antagonists in the treatment of migraine. Therefore, at the present time, molecular genetic data provide support for the hypothesis that susceptibility to migraine may be modified, in part, by variations in dopamine DRD2 receptor function.

引用

页码：S147 / S151