Spondyloarthritides

被引：4

作者：

Rudwaleit, M. ^{[1
]}

机构：

[1] Klinikum Bielefeld Rosenhohe, Klin Innere Med & Rheumatol, Rosenhohe 27, D-33647 Bielefeld, Germany

来源：

INTERNIST | 2017年 / 58卷 / 07期

关键词：

Spondylitis; ankylosing; Arthritis; psoriatic; Sacroiliitis; Anti-inflammatory agents; non-steroidal; Tumor necrosis factor alpha; inhibitors; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; SOCIETY CLASSIFICATION CRITERIA; MAJOR CLINICAL-RESPONSE; INFLAMMATORY BACK-PAIN; ANKYLOSING-SPONDYLITIS; AXIAL SPONDYLOARTHRITIS; RADIOGRAPHIC PROGRESSION; RECOMMENDATIONS; DIAGNOSIS; ARTHRITIS;

D O I：

10.1007/s00108-017-0263-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Spondyloarthritides (SpA) are inflammatory rheumatic diseases affecting the axial skeleton, peripheral joints and entheses, and also manifest at extraskeletal sites. According to the more recently introduced nomenclature, predominant axial SpA is distinguished from predominant peripheral SpA. Axial SpA is further divided into radiographic and nonradiographic axial SpA. Genetic factors are relevant, with HLA-B27 being most important. The interleukin 23/17 pathway seems to be relevant and points towards new therapeutic targets. Inflammatory back pain is the leading symptom in axial SpA and has certain characteristics. In addition, HLA-B27 and sacroiliitis on imaging are important for diagnosis. Therapy consists of physiotherapy, nonsteroidal anti-inflammatory drugs (first line) and biologicals (second line). Conventional disease-modifying antirheumatic drugs are effective only in peripheral arthritis.

引用

页码：687 / 699

页数：13

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