Dabrafenib and Trametinib prolong coagulation through the inhibition of tissue factor in BRAFv600e mutated melanoma cells in vitro

[1] Rickles FR(2003)Tissue factor, thrombin, and cancer Chest 124 58S-68S

[2] Patierno S(2009)Impact of venous thromboembolism and anticoagulation on cancer and cancer survival J Clin Oncol 27 4902-4911

[3] Fernandez PM(2008)Tissue factor, angiogenesis and tumour progression Breast Cancer Res 10 204-60

[4] Kuderer NM(2009)Procoagulant mechanisms in tumour cells Best Pract Res Clin Haematol 22 49-11836

[5] Ortel TL(1992)Expression of tissue factor by melanoma cells promotes efficient hematogenous metastasis Proc Natl Acad Sci USA 89 11832-1256

[6] Francis CW(2016)The thrombophilic status predicts prognosis in metastatic BRAFV600 mutated melanoma patients receiving BRAF inhibitors J Am Acad Dermatol 74 1254-675

[7] Bluff JE(2012)NIH Image to ImageJ: 25 years of image analysis Nat Methods 9 671-2043

[8] Brown NJ(2014)Dabrafenib and trametinib, alone and in combination for BRAF-mutant metastatic melanoma Clin Cancer Res 20 2035-8209

[9] Reed MW(2013)Activation of blood coagulation in cancer: implications for tumour progression Biosci Rep 33 e00064-1632

[10] Staton CA(1995)Tissue factor promotes melanoma metastasis by a pathway independent of blood coagulation Proc Natl Acad Sci 92 8205-560

[1] Rickles FR(2003)Tissue factor, thrombin, and cancer Chest 124 58S-68S

[2] Patierno S(2009)Impact of venous thromboembolism and anticoagulation on cancer and cancer survival J Clin Oncol 27 4902-4911

[3] Fernandez PM(2008)Tissue factor, angiogenesis and tumour progression Breast Cancer Res 10 204-60

[4] Kuderer NM(2009)Procoagulant mechanisms in tumour cells Best Pract Res Clin Haematol 22 49-11836

[5] Ortel TL(1992)Expression of tissue factor by melanoma cells promotes efficient hematogenous metastasis Proc Natl Acad Sci USA 89 11832-1256

[6] Francis CW(2016)The thrombophilic status predicts prognosis in metastatic BRAFV600 mutated melanoma patients receiving BRAF inhibitors J Am Acad Dermatol 74 1254-675

[7] Bluff JE(2012)NIH Image to ImageJ: 25 years of image analysis Nat Methods 9 671-2043

[8] Brown NJ(2014)Dabrafenib and trametinib, alone and in combination for BRAF-mutant metastatic melanoma Clin Cancer Res 20 2035-8209

[9] Reed MW(2013)Activation of blood coagulation in cancer: implications for tumour progression Biosci Rep 33 e00064-1632

[10] Staton CA(1995)Tissue factor promotes melanoma metastasis by a pathway independent of blood coagulation Proc Natl Acad Sci 92 8205-560