The physiological impact of microRNA gene regulation in the retina

被引：0
作者：
Thomas R. Sundermeier
Krzysztof Palczewski
机构：
[1] Case Western Reserve University,Department of Pharmacology, School of Medicine
来源：
Cellular and Molecular Life Sciences | 2012年 / 69卷
关键词：
microRNA; Retina; Dicer; Photoreceptor; Argonaute;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
microRNAs (miRNAs) are small, stable RNA molecules that post-transcriptionally regulate gene expression in plants and animals by base pairing to partially complementary sequences on target mRNAs to inhibit protein synthesis. More than 250 miRNAs are reportedly expressed in the retina, and miRNA gene regulation has been shown to affect retinal development, function, and disease. Here we highlight recent advances in understanding the functional roles of vertebrate retinal miRNAs. Details are emerging about the physiological impact of specific miRNAs in the developing and mature retina, and we discuss a group of emerging technologies for studying miRNAs, which can be employed to yield a deeper understanding of retinal miRNA gene regulation.
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页码：2739 / 2750
页数：11
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