Complete genome analysis of a rabies virus isolate from Brazilian wild fox

被引：0
作者：
Nobuyuki Mochizuki
Yuki Kobayashi
Go Sato
Takuya Itou
Alberio Antonio Barros Gomes
Fumio Honma Ito
Takeo Sakai
机构：
[1] Nihon University,Nihon University Veterinary Research Center
[2] National Institute of Infectious Diseases,Department of Veterinary Science
[3] Federal University of Campina Grande,Department of Veterinary Medicine, Center of Health and Rural Technology
[4] University of São Paulo,Faculty of Veterinary Medicine and Zootechny
来源：
Archives of Virology | 2009年 / 154卷
关键词：
Rabies; Rabies Virus; Antigenic Site; RABV Isolate; Complete Genome Analysis;
D O I：
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中图分类号：
学科分类号：
摘要：
The complete genome sequence of wild-type rabies virus (RABV) isolated from a wild Brazilian hoary fox (Dusicyon sp.), the BR-Pfx1 isolate, was determined and compared with fixed RABV strains. The genome structure and organization of the BR-Pfx1 isolate were composed of 11,924 nt and included the five standard genes of rhabdoviruses. Sequences of mRNA start and stop signals for transcription were highly conserved among all structural protein genes of the BR-Pfx1 isolate. All amino acid residues in the glycoprotein (G) gene associated with pathogenicity were retained in the BR-Pfx1 isolate, while unique amino acid substitutions were found in antigenic region I of the nucleoprotein gene and III of G. These results suggest that although the standard genome structure and organization of the RABV isolate are common between the BR-Pfx1 isolate and fixed RABV strains, the unique amino acid substitutions in functional sites of the BR-Pfx1 isolate may result in different biological characteristics from fixed RABV strains.
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页码：1475 / 1488
页数：13
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