Formation of human prostate tissue from embryonic stem cells

被引：0

作者：

Renea A Taylor

Prue A Cowin

Gerald R Cunha

Martin Pera

Alan O Trounson

John Pedersen

Gail P Risbridger

机构：

[1] Centre for Urological Research,Department of Anatomy

[2] Monash Institute of Medical Research,undefined

[3] Monash University,undefined

[4] Monash Immunology and Stem Cell Laboratories,undefined

[5] STRIP 1,undefined

[6] West Ring Road,undefined

[7] Monash University,undefined

[8] University of California,undefined

[9] Australian Stem Cell Centre,undefined

[10] P.O. Box 8002,undefined

[11] Monash University LPO,undefined

[12] TissuPath Laboratories,undefined

来源：

Nature Methods | 2006年 / 3卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Rodent models and immortalized or genetically modified cell lines are frequently used—but have limited utility—for studying human prostate development and maturation. Using rodent mesenchyme to establish reciprocal mesenchymal-epithelial cell interactions with human embryonic stem cells (hESCs), we generated human prostate tissue expressing prostate-specific antigen (PSA) within 8–12 weeks. This human prostate model shows species-conserved signalling mechanisms that could extend to integumental, gastrointestinal and genital tissues.

引用

页码：179 / 181

页数：2

共 28 条

[1]

vom Saal FS(1997)undefined Proc. Natl. Acad. Sci. USA 94 2056-2061

[2]

Donjacour AA(1993)undefined Endocrinology 132 2342-2350

[3]

Cunha GR(1992)undefined J. Androl. 13 465-475

[4]

Cunha GR(1987)undefined Endocr. Rev. 8 338-362

[5]

Cunha GR(2001)undefined Dev. Biol. 229 432-442

[6]

Risbridger G(1989)undefined Development 106 219-234

[7]

Higgins SJ(1995)undefined Development 121 2199-2207

[8]

Young P(2000)undefined Nat. Biotechnol. 18 399-404

[9]

Brody JR(1979)undefined Biol. Reprod. 21 455-463

[10]

Cunha GR(1996)undefined Biol. Reprod. 54 36-44

← 1 2 3 →