Weight Loss Interventions and Progression of Diabetic Kidney Disease

被引：0
作者：
Neil G. Docherty
Aoife L. Canney
Carel W. le Roux
机构：
[1] University College Dublin,Diabetes Complications Research Centre, Conway Institute, School of Medicine and Medical Sciences
[2] University of Gothenburg,Gastrosurgical Laboratory
[3] Imperial College London,Investigative Science
来源：
Current Diabetes Reports | 2015年 / 15卷
关键词：
Kidney; Diabetes; Weight loss; Surgery; Diet; Lifestyle; GFR; Proteinuria;
D O I：
暂无
中图分类号：
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摘要：
Progressive renal impairment (diabetic kidney disease (DKD)) occurs in upwards of 40 % of patients with obesity and type 2 diabetes mellitus (T2DM) and is a cause of significant morbidity and mortality. Means of attenuating the progression of DKD focus on amelioration of risk factors. Visceral obesity is implicated as a causative agent in impaired metabolic and cardiovascular control in T2DM, and various approaches primarily targeting weight have been examined for their impact on markers of renal injury and dysfunction in DKD. The current report summarises the evidence base for the impact of surgical, lifestyle and pharmacological approaches to weight loss on renal end points in DKD. The potential for a threshold of weight loss more readily achievable by surgical intervention to be a prerequisite for renal improvement is highlighted. Comparing efficacious non-surgical weight loss strategies with surgical strategies in appropriately powered and controlled prospective studies is a priority for the field.
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