Solid-phase synthesis of deuterium- and tritium-labeled dopamine using carbon nanomaterials

被引：6

作者：

Shevchenko V.P. ^{[1
]}

Nagaev I.Yu. ^{[1
]}

Shevchenko K.V. ^{[1
]}

Chernysheva M.G. ^{[2
]}

Badun G.A. ^{[2
]}

Fedoseev V.M. ^{[2
]}

Myasoedov N.F. ^{[1
]}

机构：

[1] Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182

[2] Chemical Faculty, Lomonosov Moscow State University, Building 10, Moscow, 119992

来源：

Radiochemistry | 2011年 / 53卷 / 3期

基金：

俄罗斯基础研究基金会;

关键词：

Carbon nanomaterials; Dopamine; Hydrogen isotope labeling;

D O I：

10.1134/S1066362211030192

中图分类号：

学科分类号：

摘要：

Various procedures for preparing dopamine labeled with deuterium ( 2H) and tritium (3H) were considered. The labeled dopamine into which the hydrogen isotopes were introduced by solid-phase halogenation contained, on the average, 2.8 2H (3H) atoms. The labeled dopamine prepared by solid-phase isotope exchange using nanodiamonds as support contained, on the average, 4.8 2H (3H) atoms. The process was accompanied by the substrate deamination; as a result, the yield of the labeled analog was low (7-10%). Mass spectrometric analysis shows that the phenolic fragments formed by the dopamine deamination undergo dimerization. © 2011 Pleiades Publishing, Inc.

引用

页码：336 / 340

页数：4

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