rs4771122 Predicts Multiple Measures of Long-Term Weight Loss After Bariatric Surgery

被引：0
作者：
Laura J. Rasmussen-Torvik
Abigail S. Baldridge
Jennifer A. Pacheco
Sharon A. Aufox
Kwang-Youn A. Kim
Jonathan C. Silverstein
Erwin W. Denham
Eric Hungness
Maureen E. Smith
Philip Greenland
机构：
[1] Northwestern University Feinberg School of Medicine,Department of Preventive Medicine
[2] Northwestern University Feinberg School of Medicine,Center for Genetic Medicine
[3] NorthShore University Health System,NorthShore Research Institute
[4] Northwestern University Feinberg School of Medicine,Department of Surgery
来源：
Obesity Surgery | 2015年 / 25卷
关键词：
Bariatric surgery; Repeated measures; Predictors; Long-term weight loss; Roux-en-Y gastric bypass; SNP; Obesity GWAS;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We examined the association of 34 single nucleotide polymorphisms with weight loss up to 9.5 years after Roux-en-Y surgery. Participants were enrollees in the NUgene biobank with stored DNA and linked electronic health records. Ninety-five self-identified white participants underwent surgery and had follow-up weights obtained between 1 and 9.5 years after surgery. SNP rs4771122 was the variant most significantly associated with long-term weight loss after surgery in a repeated linear mixed model (p = .004) of long-term weight loss. In this model, each additional copy of the minor allele was associated with nearly 5 % greater percentage weight loss. This same SNP was also nominally significantly (p < .05) associated with weight loss trajectories, weight loss nadir, and weight loss 2 years after surgery.
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页码：2225 / 2229
页数：4
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共 20 条
  • [1] Speliotes EK(2010)Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index Nat Genet 42 937-48
  • [2] Willer CJ(2010)Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution Nat Genet 42 949-60
  • [3] Berndt SI(2013)Advantages of percent weight loss as a method of reporting weight loss after roux-en-Y gastric bypass Obesity (Silver Spring) 21 1519-25
  • [4] Heid IM(2011)The MC4R(I251L) allele is associated with better metabolic status and more weight loss after gastric bypass surgery J Clin Endocrinol Metab 96 E2088-96
  • [5] Jackson AU(2013)Weight loss after gastric bypass is associated with a variant at 15q26.1 Am J Hum Genet 92 827-34
  • [6] Randall JC(2013)Genome-wide association of single-nucleotide polymorphisms with weight loss outcomes after roux-en-Y gastric bypass surgery J Clin Endocrinol Metab 98 E1131-6
  • [7] Hatoum IJ(2013)Contribution of 32 GWAS-identified common variants to severe obesity in European adults referred for bariatric surgery PLoS One 8 e70735-undefined
  • [8] Kaplan LM(undefined)undefined undefined undefined undefined-undefined
  • [9] Mirshahi UL(undefined)undefined undefined undefined undefined-undefined
  • [10] Still CD(undefined)undefined undefined undefined undefined-undefined
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