5-HT Modulation of Dopamine Release in Basal Ganglia in Psilocybin-Induced Psychosis in Man—A PET Study with [11C]raclopride

被引：0

作者：

Franz X Vollenweider

Peter Vontobel

Daniel Hell

Klaus L Leenders

机构：

[1] Psychiatric University Hospital Zu¨rich,Research Department

[2] Paul Scherrer Institute,PET Department

[3] University Hospital Zu¨rich,Neurology Department

来源：

Neuropsychopharmacology | 1999年 / 20卷

关键词：

Psilocybin; Indoleamine hallucinogen; Model psychosis; Serotonin; 5-HT; receptor; 5-HT; receptor; Dopamine; D; receptor; Striatum; Psychopathology; Human; Schizophrenia; Positron Emission Tomography (PET); [; C]raclopride;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The modulating effects of serotonin on dopamine neurotransmission are not well understood, particularly in acute psychotic states. Positron emission tomography was used to examine the effect of psilocybin on the in vivo binding of [11C]raclopride to D2-dopamine receptors in the striatum in healthy volunteers after placebo and a psychotomimetic dose of psilocybin (). Psilocybin is a potent indoleamine hallucinogen and a mixed 5-HT2A and 5-HT1A receptor agonist. Psilocybin administration (0.25 mg/kg p.o.) produced changes in mood, disturbances in thinking, illusions, elementary and complex visual hallucinations and impaired ego-functioning. Psilocybin significantly decreased [11C]raclopride receptor binding potential (BP) bilaterally in the caudate nucleus (19%) and putamen (20%) consistent with an increase in endogenous dopamine. Changes in [11C]raclopride BP in the ventral striatum correlated with depersonalization associated with euphoria. Together with previous reports of 5-HT receptor involvement in striatal dopamine release, it is concluded that stimulation of both 5-HT2A and 5-HT1A receptors may be important for the modulation of striatal dopamine release in acute psychoses. The present results indirectly support the hypothesis of a serotonin-dopamine dysbalance in schizophrenia and suggest that psilocybin is a valuable tool in the analysis of serotonin-dopamine interactions in acute psychotic states.

引用

页码：424 / 433

页数：9

共 351 条

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