Exploring the Role of Ag Nanoparticle Distribution in Novel pH-Sensitive Nanofibers Containing Hyaluronic Acid for Enhanced Wound Healing with Sustained Curcumin Release

被引：0
作者：
Zahra Sayyar
Mahsa Khadem Sadigh
机构：
[1] University of Bonab,Department of Chemical Engineering
[2] University of Bonab,Department of Laser and Optics Engineering
来源：
Fibers and Polymers | 2024年 / 25卷
关键词：
Nanofibers; Ag nanoparticles; Curcumin; Hyaluronic acid; Drug release; Wound healing;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The use of nanofiber patches has received considerable attention as a promising solution for overcoming challenges in drug delivery. In this study, silver nanoparticles (Ag NPs) were incorporated in chitosan (CS), hyaluronic acid (HYA), and polyvinyl alcohol (PVA) to form nanofibers (namely, the CS/HYA/PVA-Ag nanofiber) for the controllable release of curcumin (CUR). The CUR release from the CS/HYA/PVA-Ag nanofibers consistently happened sustainably. Therefore, the prepared CS/HYA/PVA-Ag nanofibers show great promise in terms of their ability to expand the field of pH-dependent transdermal drug delivery (TDD) and sustainably release drugs. Additionally, the scratch assay results of these nanofibers further support their potential applications in wound healing.
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页码：1163 / 1176
页数：13
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  • [1] Zou P(2020)Wound dressing from polyvinyl alcohol/chitosan electrospun fiber membrane loaded with OH-CATH30 nanoparticles Carbohyd. Polym. 232 66-6136
  • [2] Lee W-H(2023)A novel transdermal delivery route for energy supplements: electrospun chitosan/polyvinyl alcohol nanofiber patches loaded with vitamin B12 Int. J. Biol. Macromol. 230 6132-359
  • [3] Gao Z(2023)Dual-drug (Curcumin/Ciprofloxacin) loading and release from chitosan-based hydrogels embedded with magnetic Montmorillonite/Hyaluronic acid for enhancing wound healing J. Biol. Eng. 17 351-220
  • [4] Qin D(2020)Polymer nanocomposite meshes for flexible electronic devices Prog. Polym. Sci. 107 210-129
  • [5] Wang Y(2020)Electrospinning of natural polymers for the production of nanofibres for wound healing applications Mater. Sci. Eng. C 114 11937-803
  • [6] Liu J(2024)Developing curcumin loaded-magnetic montmorillonite nanoparticles/polyvinyl alcohol/hyaluronic acid/chitosan nanofiber mats as a wound dressing J. Drug Deliv. Sci. Technol. 93 112-146
  • [7] Sun T(2023)A review on polysaccharides mediated electrospun nanofibers for diabetic wound healing: their current status with regulatory perspective Int. J. Biol. Macromol. 234 781-18
  • [8] Gao Y(2017)Structure-property relationship of cellulose nanowhiskers reinforced chitosan biocomposite films J. Environ. Chem. Eng. 5 2515221118769324-959
  • [9] Yekrang J(2021)Biopolymers and composites: properties, characterization and their applications in food, medical and pharmaceutical industries J. Environ. Chem. Eng. 9 2683-19
  • [10] Gholam-Shahbazi N(2021)Chitosan modified by organo-functionalities as an efficient nanoplatform for anti-cancer drug delivery process J. Drug Deliv. Sci. Technol. 62 3428-153
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