NK cells and cancer immunosurveillance

被引：0
作者：
I Waldhauer
A Steinle
机构：
[1] Interfacultary Institute for Cell Biology,Department of Immunology
[2] Eberhard Karls University of Tübingen,undefined
来源：
Oncogene | 2008年 / 27卷
关键词：
NK cells; NKG2D; innate immunity; cancer immunosurveillance;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Natural killer (NK) cells are lymphocytes of the innate immune system that monitor cell surfaces of autologous cells for an aberrant expression of MHC class I molecules and cell stress markers. Since their first description more than 30 years ago, NK cells have been implicated in the immune defence against tumours. Here, we review the broadly accumulating evidence for a crucial contribution of NK cells to the immunosurveillance of tumours and the molecular mechanisms that allow NK cells to distinguish malignant from healthy cells. Particular emphasis is placed on the activating NK receptor NKG2D, which recognizes a variety of MHC class I-related molecules believed to act as ‘immuno-alerters’ on malignant cells, and on tumour-mediated counterstrategies promoting escape from NKG2D-mediated recognition.
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页码：5932 / 5943
页数：11
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