Inhalation of 7.5% carbon dioxide increases alerting and orienting attention network function

Abrams K(2006)Evidence for respiratory and nonrespiratory subtypes in panic disorder Depression Anxiety 23 474-481

Rassovsky Y(2005)An integrative theory of locus coeruleus-norepinephrine function: Adaptive gain and optimal performance Annu Rev Neurosci 28 403-450

Kushner MG(2008)GABA-A receptors and the response to CO2 inhalation - A translational trans-species model of anxiety? Pharmacol Biochem Behav 90 51-57

Aston-Jones G(2003)Does the brain noradrenaline network mediate the effects of the CO2 challenge? J Psychopharmacol 17 252-259

Cohen JD(2005)Behavioral and cardiovascular effects of 7.5 % CO2 in human volunteers Depression Anxiety 21 18-25

Bailey JE(2007)A validation of the 7.5% CO2 model of GAD using paroxetine and lorazepam in healthy volunteers J Psychopharmacol 21 42-49

Nutt DJ(2011)Validating the inhalation of 7.5% CO(2) in healthy volunteers as a human experimental medicine: a model of generalized anxiety disorder (GAD) J Psychopharmacol 25 1192-1198

Bailey JE(2011)Preliminary evidence of anxiolytic effects of the CRF(1) receptor antagonist R317573 in the 7.5% CO(2) proof-of-concept experimental model of human anxiety J Psychopharmacol 25 1199-1206

Argyropoulos SV(2007)Threat-related attentional bias in anxious and nonanxious individuals: A meta-analytic study Psychol Bull 133 1-24

Lightman SL(2007)Neurocognitive mechanisms of anxiety: an integrative account Trends Cogn Sci 11 307-316

Abrams K(2006)Evidence for respiratory and nonrespiratory subtypes in panic disorder Depression Anxiety 23 474-481

Rassovsky Y(2005)An integrative theory of locus coeruleus-norepinephrine function: Adaptive gain and optimal performance Annu Rev Neurosci 28 403-450

Kushner MG(2008)GABA-A receptors and the response to CO2 inhalation - A translational trans-species model of anxiety? Pharmacol Biochem Behav 90 51-57

Aston-Jones G(2003)Does the brain noradrenaline network mediate the effects of the CO2 challenge? J Psychopharmacol 17 252-259

Cohen JD(2005)Behavioral and cardiovascular effects of 7.5 % CO2 in human volunteers Depression Anxiety 21 18-25

Bailey JE(2007)A validation of the 7.5% CO2 model of GAD using paroxetine and lorazepam in healthy volunteers J Psychopharmacol 21 42-49

Nutt DJ(2011)Validating the inhalation of 7.5% CO(2) in healthy volunteers as a human experimental medicine: a model of generalized anxiety disorder (GAD) J Psychopharmacol 25 1192-1198

Bailey JE(2011)Preliminary evidence of anxiolytic effects of the CRF(1) receptor antagonist R317573 in the 7.5% CO(2) proof-of-concept experimental model of human anxiety J Psychopharmacol 25 1199-1206

Argyropoulos SV(2007)Threat-related attentional bias in anxious and nonanxious individuals: A meta-analytic study Psychol Bull 133 1-24

Lightman SL(2007)Neurocognitive mechanisms of anxiety: an integrative account Trends Cogn Sci 11 307-316