Antiendothelial cell antibodies as the tip of the iceberg: What is hidden underneath?

被引：0
作者：
M. M. Ziganshina
O. A. Sergunina
M. A. Nikolaeva
G. T. Sukhikh
机构：
[1] Ministry of Health of the Russian Federation,Kulakov Research Center for Obstetrics, Gynecology, and Perinatology
来源：
Biology Bulletin Reviews | 2017年 / 7卷 / 6期
关键词：
endothelium; antiendothelial cell antibodies (AECAs); endothelial activation/dysfunction; molecular targets; pregnancy;
D O I：
10.1134/S207908641706010X
中图分类号：
学科分类号：
摘要：
A system analysis of the published data on antiendothelial cell antibodies (AECAs) was performed. The AECAs target antigens on endothelial cells are characterized, the methodology of revealing AECAs is described, and the role of antibodies in the pathogenesis of processes caused by the activation/dysfunction of endothelium is considered. The review summarizes the present-day results of Russian and international studies published in the last 25 years in the Pubmed, High Wire, and e-Library databases. The characteristics of natural and disease-associated AECAs (related to pathology) and mechanisms of their influence on cells in different pathologies are presented.
引用
收藏
页码：537 / 546
页数：9
相关论文
共 145 条
[1]  
Aird W.C.(2008)Endothelium in health and disease Pharmacol. Rep. 60 139-143
[2]  
Alessandri C.(2006)Pathogenic mechanisms of anti-endothelial cell antibodies (AECA): their prevalence and clinical relevance Adv. Clin. Chem. 42 297-326
[3]  
Bombardieri M.(2012)Detection of complement-fixing and non-fixing antibodies specific for endothelial precursor cells and lymphocytes using flow cytometry Tissue Antigens 80 404-415
[4]  
Valesini G.(2005)Expression of integrins and adhesive properties of human endothelial cell line EA.hy 926 Cancer Genomics Proteomics 2 3-7
[5]  
Al Mahri A.(2006)Antiendothelial cell antibodies in vasculitis and con nective tissue disease Ann. Rheum. Dis. 65 1545-1550
[6]  
Holgersson J.(2001)Functional heterogeneity of anti-endothelial antibodies Clin. Exp. Immunol. 124 492-501
[7]  
Alheim M.(1999)IgG antiendothelial cell antibodies from patients with systemic lupus erythematosus or systemic vasculitis stimulate the release of two endothelial cell-derived mediators, which enhance adhesion molecule expression and leukocyte adhesion in a autocrine manner Arthritis Rheum. 42 631-640
[8]  
Baranska P.(2008)Vasculopathy and vasculitis in systemic lupus erythematosus Pol. Arch. Med. Wewn. 118 57-63
[9]  
Jerczynska H.(1998)Endothelial cells in physiology and in the pathophysiology of vascular disorders Blood 91 3527-3561
[10]  
Pawlowska Z.(2003)Anti-endothelial cell antibodies and soluble markers of endothelial cell dysfunction in systemic lupus erythematosus J. Rheumatol. 30 1963-1966
12345678910