Effectiveness of the 23-valent pneumococcal polysaccharide vaccine against invasive pneumococcal disease among 948,263 individuals ≥ 65 years of age: a Danish cohort study

被引：0
作者：
Katrine Finderup Nielsen
Lise Birk Nielsen
Frederikke Kristensen Lomholt
Sarah Kristine Nørgaard
Hans-Christian Slotved
Tine Dalby
Kurt Fuursted
Charlotte Sværke Jørgensen
Palle Valentiner-Branth
机构：
[1] Statens Serum Institut,Department of Infectious Disease Epidemiology and Prevention
[2] Statens Serum Institut,Department of Bacteria, Parasites and Fungi
[3] Statens Serum Institut,Department of Microbiological Special Diagnostics
来源：
European Journal of Clinical Microbiology & Infectious Diseases | 2022年 / 41卷
关键词：
Pneumococcal polysaccharide vaccine; Vaccine effectiveness; Invasive pneumococcal disease; Epidemiology;
D O I：
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中图分类号：
学科分类号：
摘要：
This study aimed to estimate the effectiveness of the 23-valent pneumococcal polysaccharide vaccine (PPV23) against invasive pneumococcal disease (IPD) among individuals ≥ 65 years of age. We used Danish nationwide databases to obtain information on PPV23 vaccination, covariates, and IPD and linked data on an individual level using a unique personal identifier. A total of 948,263 individuals were included and followed between June 15, 2020, and September 18, 2021 (58.6% were vaccinated during follow-up). The adjusted vaccine effectiveness was 42% (95% confidence interval (CI): 9–63%) for all-serotype IPD and 58% (95% CI: 21–78%) for PPV23-serotype IPD, using no vaccination as the reference.
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页码：1473 / 1477
页数：4
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