Oxysterols are allosteric activators of the oncoprotein Smoothened

被引：0
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作者：
Sigrid Nachtergaele
Laurel K Mydock
Kathiresan Krishnan
Jayan Rammohan
Paul H Schlesinger
Douglas F Covey
Rajat Rohatgi
机构：
[1] Stanford University School of Medicine,Department of Biochemistry
[2] Washington University School of Medicine,Department of Developmental Biology
[3] Washington University School of Medicine,Department of Cell Biology and Physiology
[4] Stanford University School of Medicine,Department of Medicine
来源：
Nature Chemical Biology | 2012年 / 8卷
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摘要：
20(S)-hydroxycholesterol binds to Smo at a site distinct from cyclopamine and activates signaling via an allosteric mechanism. A new alkyne oxysterol analog selectively captures Smo from membrane extracts and provides a new method for detecting protein-sterol interactions.[graphic not available: see fulltext]
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页码：211 / 220
页数：9
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