Oxysterols are allosteric activators of the oncoprotein Smoothened

被引：0
|
作者：
Sigrid Nachtergaele
Laurel K Mydock
Kathiresan Krishnan
Jayan Rammohan
Paul H Schlesinger
Douglas F Covey
Rajat Rohatgi
机构：
[1] Stanford University School of Medicine,Department of Biochemistry
[2] Washington University School of Medicine,Department of Developmental Biology
[3] Washington University School of Medicine,Department of Cell Biology and Physiology
[4] Stanford University School of Medicine,Department of Medicine
来源：
Nature Chemical Biology | 2012年 / 8卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
20(S)-hydroxycholesterol binds to Smo at a site distinct from cyclopamine and activates signaling via an allosteric mechanism. A new alkyne oxysterol analog selectively captures Smo from membrane extracts and provides a new method for detecting protein-sterol interactions.[graphic not available: see fulltext]
引用
收藏
页码：211 / 220
页数：9
相关论文
共 50 条
  • [1] Oxysterols are allosteric activators of the oncoprotein Smoothened
    Nachtergaele, Sigrid
    Mydock, Laurel K.
    Krishnan, Kathiresan
    Rammohan, Jayan
    Schlesinger, Paul H.
    Covey, Douglas F.
    Rohatgi, Rajat
    NATURE CHEMICAL BIOLOGY, 2012, 8 (02) : 211 - 220
  • [2] Oxysterols are allosteric activators of the oncoprotein Smoothened.
    Nachtergaele, S.
    Mydock, L. K.
    Krishnan, K.
    Rammohan, J.
    Schlesinger, P. H.
    Covey, D. F.
    Rohatgi, R.
    MOLECULAR BIOLOGY OF THE CELL, 2012, 23
  • [3] Cilia-Associated Oxysterols Activate Smoothened
    Raleigh, David R.
    Sever, Navdar
    Choksi, Pervinder K.
    Sigg, Monika Abedin
    Hines, Kelly M.
    Thompson, Bonne M.
    Elnatan, Daniel
    Jaishankar, Priyadarshini
    Bisignano, Paola
    Garcia-Gonzalo, Francesc R.
    Krup, Alexis Leigh
    Eberl, Markus
    Byrne, Eamon F. X.
    Siebold, Christian
    Wong, Sunny Y.
    Renslo, Adam R.
    Grabe, Michael
    McDonald, Jeffrey G.
    Xu, Libin
    Beachy, Philip A.
    Reiter, Jeremy F.
    MOLECULAR CELL, 2018, 72 (02) : 316 - +
  • [4] Regulation of the oncoprotein Smoothened by small molecules
    Sharpe, Hayley J.
    Wang, Weiru
    Hannoush, Rami N.
    de Sauvage, Frederic J.
    NATURE CHEMICAL BIOLOGY, 2015, 11 (04) : 246 - 255
  • [5] Regulation of the oncoprotein Smoothened by small molecules
    Sharpe H.J.
    Wang W.
    Hannoush R.N.
    De Sauvage F.J.
    Nature Chemical Biology, 2015, 11 (4) : 246 - 255
  • [6] The mechanism of Smoothened regulation by oxysterols in vertebrate Hedgehog signaling
    Nachtergaele, S.
    Whalen, D.
    Mydock, L. K.
    Covey, D. F.
    Siebold, C.
    Rohatgi, R.
    MOLECULAR BIOLOGY OF THE CELL, 2013, 24
  • [7] The mechanism of Smoothened regulation by oxysterols in vertebrate Hedgehog signaling.
    Nachtergaele, S.
    Whalen, D.
    Mydock, L.
    Covey, D.
    Siebold, C.
    Rohatgi, R.
    MOLECULAR BIOLOGY OF THE CELL, 2013, 24
  • [8] Targeting the Oncoprotein Smoothened by Small Molecules: Focus on Novel Acylguanidine Derivatives as Potent Smoothened Inhibitors
    Pietrobono, Silvia
    Stecca, Barbara
    CELLS, 2018, 7 (12)
  • [9] Oxysterols are novel activators of hedgehog and Wnt signaling.
    Amantea, C. M.
    Dwyer, J. A.
    Sever, N.
    Beachy, P. A.
    Kim, W.
    Hahn, T. J.
    Tetradis, S.
    Parhami, F.
    JOURNAL OF BONE AND MINERAL RESEARCH, 2006, 21 : S157 - S157
  • [10] Synthesis and Evaluation of Osteogenic Oxysterols as Hedgehog Pathway Activators
    Maschinot, Chad A.
    Corman, Audrey R.
    DeBerardinis, Albert M.
    Hadden, M. Kyle
    CHEMMEDCHEM, 2016, 11 (07) : 679 - 686
12345