Identification of Pathogenic CNVs in Unexplained Developmental Disabilities Using Exome Sequencing: A Family Trio Study

被引:0
作者
O. Yu. Naumova
P. V. Dobrynin
E. A. Gibitova
M. A. Zhukova
S. Yu. Rychkov
O. V. Zhukova
E. L. Grigorenko
机构
[1] Vavilov Institute of General Genetics,
[2] Russian Academy of Sciences,undefined
[3] University of Houston,undefined
[4] University of Information Technologies,undefined
[5] Mechanics and Optics,undefined
[6] Saint Petersburg State University,undefined
来源
Russian Journal of Genetics | 2021年 / 57卷
关键词
unexplained developmental disorders and delays; family study; exome sequencing; structural genomic variation;
D O I
暂无
中图分类号
学科分类号
摘要
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页码:1351 / 1355
页数:4
相关论文
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[1]  
Tărlungeanu D.C.(2018)Genomics in neurodevelopmental disorders: an avenue to personalized medicine Ex. Mol. Med. 50 1-7
[2]  
Novarino G.(2017)Genomic diagnosis for children with intellectual disability and/or developmental delay Genome Med. 9 43-202
[3]  
Bowling K.M.(2020)Genetic tests by next-generation sequencing in children with developmental delay and/or intellectual disability Clin. Exp. Pediatr. 63 195-2421
[4]  
Thompson M.L.(2019)Meta-analysis and multidisciplinary consensus statement: exome sequencing is a first-tier clinical diagnostic test for individuals with neurodevelopmental disorders Genet. Med. 21 2413-770
[5]  
Amaral M.D.(2011)A fast, lock-free approach for efficient parallel counting of occurrences of k-mers Bioinformatics 27 764-1760
[6]  
Han J.Y.(2009)Fast and accurate short read alignment with Burrows—Wheeler transform Bioinformatics 25 1754-D1067
[7]  
Lee I.G.(2012)cn.MOPS: mixture of Poissons for discovering copy number variations in next-generation sequencing data with a low false discovery rate Nucleic Acids Res. 40 e69-1081
[8]  
Srivastava S.(2010)ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data Nucleic Acids Res. 38 e164-362
[9]  
Love-Nichols J.A.(2018)ClinVar: improving access to variant interpretations and supporting evidence Nucleic Acids Res. 46 D1062-1586
[10]  
Dies K.A.(2009)Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm Nat. Protoc. 4 1073-D894