A comprehensive overview of the role of the RET proto-oncogene in thyroid carcinoma

被引：0
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作者：
Cristina Romei
Raffaele Ciampi
Rossella Elisei
机构：
[1] Endocrine Unit,Department of Clinical and Experimental Medicine
[2] University of Pisa,undefined
来源：
Nature Reviews Endocrinology | 2016年 / 12卷
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摘要：
RET proto-oncogene alterations are crucial events for thyroid cancer developmentDifferent mechanisms of RET activation, point mutations and gene rearrangements characterize medullary and papillary thyroid carcinomaRET genetic screening is an important tool for the diagnosis of patients with medullary thyroid cancer and can assist in the presurgical diagnosis of papillary thyroid cancerRET mutations are a very strong factor for poor prognosis in medullary thyroid cancerRET/PTC rearrangements, especially RET/PTC3, are associated with the most aggressive histological variant of papillary thyroid cancerThe knowledge of tumour biology is crucial for the identification of drugs able to block tumour development
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页码：192 / 202
页数：10
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