IgG4-related inflammatory pseudotumor of the brain parenchyma: a case report and literature review

被引：0
作者：
Zhuqing Zhang
Weiwei Fu
Minghui Wang
Lei Niu
Bin Liu
Yingbin Jiao
Xuejun Liu
机构：
[1] The Affiliated Hospital of Qingdao University,Department of Radiology
[2] The Affiliated Hospital of Qingdao University,Department of Pathology
[3] The Affiliated Hospital of Qingdao University,Department of Rheumatology
[4] The Affiliated Hospital of Qingdao University,Department of Neurosurgery
来源：
Acta Neurologica Belgica | 2018年 / 118卷
关键词：
IgG4; Inflammatory pseudotumor; Brain parenchymal; Calcification;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A 29-year-old male with a 4-month history of binocular temporal visual field defect, 1-month history of memory loss and 5-day history of headache was admitted to our hospital. Brain MRI showed progressive signal abnormalities in the brain parenchyma. His laboratory tests showed elevated serum IgG4 and liver dysfunction. Abdominal CT, ultrasound and liver biopsy showed chronic liver disease. According to the diagnostic criteria of IgG4-related disease, IgG4-related inflammatory pseudotumor of brain parenchyma was considered. After methylprednisolone treatment, his symptoms improved and brain lesion reduced. This is the second reported case of a tumefactive lesion of the brain with serum IgG4 elevation, which was responsive to steroid treatment. Coincidentally, his mother had similar medical history and imaging findings, and was subspecialty diagnosed with the same disease, but without pathological and immunohistochemical confirmation. This suggests that the disease may be hereditary. It is important to recognize IgG4-related inflammatory pseudotumors of the brain parenchyma so that patients do not undergo unnecessary surgical or other procedures.
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页码：617 / 627
页数：10
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