Synthesis and Anticancer Activity of Podophyllotoxin Derivatives

被引：0

作者：

K. Lin

X. Zhang

X. Dai

L. Ma

K. Bozorov

H. Guo

G. Huang

J. Cao

机构：

[1] Chinese Academy of Sciences,Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry

[2] University of Chinese Academy of Sciences,College of Life Sciences

[3] Shanghai Normal University,College of Chemistry and Chemical Engineering

[4] Anhui University of Technology,Institute of Chemistry of Plant Substances

[5] Academy of Sciences of Uzbekistan,undefined

来源：

Chemistry of Natural Compounds | 2021年 / 57卷

关键词：

lignan; podophyllotoxin; structural modification; anticancer activity; MCF-7;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Two series of podophyllotoxin derivatives were synthesized by addition of a 4β-sulfanilamide to or substitution of a 4β-amide into podophyllotoxin. Their cytotoxicities were evaluated against four human cancer cell lines (A549, HeLa, MCF-7, and PC-3). Investigations of the structure–activity relationship were generalized. Derivative 9f (2-thienoylaminoepipodophyllotoxin) exhibited the highest activity against the cancer cells, inhibiting growth of MCF-7 cells with IC50 0.67 ± 0.37 μM. A change in the morphology of MCF-7 cells treated with 9f also confirmed its activity as a cytotoxic derivative against cancer cells.

引用

页码：1010 / 1018

页数：8

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