Exploration of Intestinal Calcium Precipitation as a Barrier to Absorption at High Calcium Doses

被引:0
作者
Sandra Goss
Pauline Rafferty
Jennifer Prushko
Eric Gorman
Mitchell Taub
Robin Bogner
机构
[1] University of Connecticut,School of Pharmacy, U
[2] Boehringer-Ingelheim Pharmaceuticals,3092
[3] Inc.,undefined
[4] Drug Metabolism and Pharmacokinetics,undefined
来源
Pharmaceutical Research | 2008年 / 25卷
关键词
calcium absorption; calcium supplements; intestinal CO; intestinal HCO; precipitation; Caco-2 transport;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:2760 / 2768
页数:8
相关论文
共 95 条
  • [1] Dawson-Hughes B.(1990)A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women N. Engl. J. Med 323 878-883
  • [2] Dallal G.(1998)Calcium supplementation suppresses bone resorption in early postmenopausal women Calcif. Tissue Int 62 8-12
  • [3] Krall E.(2003)Calcium, vitamin D, and nutrition in elderly adults Clin. Geriatr 19 321-335
  • [4] Sadowski L.(1999)Absorption of calcium salts as the carbonate and citrate salts, with some observations on method Osteoporos Int 9 19-23
  • [5] Sahyoun N.(1999)Pharmacokinetics of calcium absorption from two commercial calcium supplements J. Clin. Pharmacol 39 1151-1154
  • [6] Tannenbaum S.(2005)Effects of proton pump inhibitors on calcium carbonate absorption in women: a randomized crossover trial Am. J. Med 118 778-781
  • [7] Scopacasa F.(2001)Influence of physicochemical properties on dissolution of drugs in the gastrointestinal tract Adv. Drug. Deliv. Rev 46 75-87
  • [8] Horowitz M.(1999)An integrated model for determining causes of poor oral drug absorption Pharm. Res 16 1883-1887
  • [9] Wishart J.(2003)Mechanisms of intestinal calcium absorption J. Cell. Biochem 88 387-393
  • [10] Need A.(1981)Effect of calcium intake on saturable and nonsaturable components of duodenal calcium transport Am. J. Phys 240 G32-G37