The Normal and Malignant Mammary Gland: A Fresh Look with ERβ Onboard

被引：0
作者：
Margaret Warner
Shigehira Saji
Jan-Åke Gustafsson
机构：
[1] Karolinska Institute,Department of Bioscience
[2] NOVUM,Department of Medical Nutrition
[3] Karolinska Institute,Department of Bioscience
[4] NOVUM,undefined
[5] Karolinska Institute,undefined
[6] NOVUM,undefined
来源：
Journal of Mammary Gland Biology and Neoplasia | 2000年 / 5卷
关键词：
estrogen receptorβ; mammary gland;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Estrogens are important for the development and function of the normal mammary gland as well as for development of mammary cancer. The frontline therapy for treatment of estrogen receptor (ERα)4 positive breast cancer is antiestrogens. A second estrogen receptor (ERβ) is also expressed in the breast but it has not been measured because it is not detected by the immunoassays used to detect ERα. In many cell systems ERβ has actions which are opposite to those of ERα and this finding has raised questions about the role of ERβ in the development and treatment of breast cancer.
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页码：289 / 294
页数：5
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