Compliance and fixed-dose combination therapy

被引:0
作者
Sripal Bangalore
Anupama Shahane
Sanobar Parkar
Franz H. Messerli
机构
[1] University College of Physicians and Surgeons,Hypertension Program, Division of Cardiology, Columbia
[2] St. Luke’s-Roosevelt Hospital Center,undefined
来源
Current Hypertension Reports | 2007年 / 9卷
关键词
Amlodipine; Felodipine; Perindopril; Medication Possession Ratio; Benazepril;
D O I
暂无
中图分类号
学科分类号
摘要
Despite data on the importance of blood pressure control in preventing cardiovascular and cerebrovascular events, only 34% of hypertensive patients have their blood pressure under control. The National Council on Patient Information and Education has estimated that the compliance rate is just over 30% for chronic conditions like hypertension. Polypharmacy and complex treatment regimens have been identified as important, modifiable risk factors for medication noncompliance. Fixed-dose combination regimens are attractive options because of the improved antihypertensive efficacy resulting from the dual mechanistic action of components targeting different effector mechanisms. One drug in the fixed-dose combination may negate an adverse effect of the other medication. Above all, fixed-dose combination therapy reduces pill burden and improves medication compliance, which can translate into better cardiovascular outcomes. Fixed-dose combinations should be used routinely for the management of hypertension and should also be considered when initiating therapy for patients with newly diagnosed hypertension.
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页码:184 / 189
页数:5
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