Thermodynamic quantities for the oxidation of ranitidine by diperiodatocuprate(III) in aqueous alkaline medium

被引：0

作者：

T. M. Veeresh

R. K. Patil

Sharanappa T. Nandibewoor

机构：

[1] Karnatak University,P.G. Department of Studies in Chemistry

来源：

Transition Metal Chemistry | 2008年 / 33卷

关键词：

Ranitidine; Periodate; Unit Order; Slow Step; KIO4;

D O I：

暂无

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学科分类号：

摘要：

The kinetics of oxidation of the anti-ulcer drug, ranitidine hydrochloride (RNH) by diperiodatocuprate(III) (DPC) in alkaline medium was studied spectrophotometrically. The reaction exhibits 1:2 stoichiometry (ranitidine:DPC). The reaction is of first order in [DPC] and has less than unit order in [RNH] and negative fractional order in [alkali]. The involvement of free radicals was observed in the reaction. The oxidation has been found to proceed via a DPC-ranitidine complex, which decomposes slowly in a rate-determining step followed by other fast steps to give the products, which were identified as ranitidine sulfoxide by spot test and spectroscopic studies.

引用

页码：981 / 988

页数：7