Role of perfusion-weighted imaging at 3 Tesla in the assessment of malignancy of cerebral gliomas

被引：31

作者：

Di Costanzo A. ^{[1
]}

Pollice S. ^{[2
]}

Trojsi F. ^{[3
]}

Giannatempo G.M. ^{[4
]}

Popolizio T. ^{[4
]}

Canalis L. ^{[2
]}

Armillotta M. ^{[5
]}

Maggialetti A. ^{[6
]}

Carriero A. ^{[2
]}

Tedeschi G. ^{[3
]}

Scarabino T. ^{[4
,6
]}

机构：

[1] Dipartimento di Scienze Per la Salute, Università degli Studi del Molise, Campobasso 86100, Via Giovanni Paolo II

[2] Istituto di Radiologia, Università del Piemonte Orientale, Novara

[3] Dipartimento di Scienze Neurologiche, Seconda Università di Napoli, Napoli

[4] Dipartimento of Neuroradiologia, IRCCS Casa Sollievo Della Sofferenza, San Giovanni Rotondo (FG)

[5] Dipartimento di Diagnostica Per Immagini, IRCCS Casa Sollievo Della Sofferenza, San Giovanni Rotondo (FG)

[6] Dipartimento di Diagnostica Per Immagini, AUSL BAT 1, Ospedale L Bonomo, Andria

来源：

La radiologia medica | 2008年 / 113卷 / 1期

关键词：

Brain tumour; Cerebral blood volume; Magnetic resonance imaging; Perfusion magnetic resonance imaging;

D O I：

10.1007/s11547-008-0232-2

中图分类号：

学科分类号：

摘要：

Purpose. This study was performed to clarify the role of perfusion-weighted imaging (PWI) at 3 Tesla in the characterisation of haemodynamic heterogeneity within gliomas and surrounding tissues and in the differentiation of high-grade from low-grade gliomas. Materials and methods. We examined 36 patients with histologically verified gliomas (25 with high-grade and 11 with low-grade gliomas). PWI was performed by first-pass gadopentetate dimeglumine T2*-weighted echo-planar images, and cerebral blood volume (CBV) maps were computed with a nondiffusible tracer model. Relative CBV (rCBV) was calculated by dividing CBV in pathological areas by that in contralateral white matter. Results. In high-grade gliomas, rCBV were markedly increased in mass [mean±standard deviation (SD), 4.3±1.2] and margins (4.0±1.1) and reduced in necrotic areas (0.3±0.3). Oedematous-appearing areas were divided in two groups according to signal intensity on T2-weighted images: tumour with lower (nearly isointense to grey matter) and oedema with higher (scarcely isointense to cerebrospinal fluid) signal intensity. Tumour showed significantly higher rCBV than did oedema (1.8±0.5 vs. 0.5±0.2; p<0.001) areas. In low-grade gliomas, mass (2.0±1.5) and margin (2.2±1.2) rCBV were significantly lower than in high-grade gliomas (p<0.001). Conclusions. Three-Tesla PWI helps to distinguish necrosis from tumour mass, infiltrating tumour from oedema and high-grade from low-grade gliomas. It enhances the magnetic resonance (MR) assessment of cerebral gliomas and provides useful information for planning surgical and radiation treatment. © 2008 Springer-Verlag.

引用

页码：134 / 143

页数：9

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