Role of the Antiangiogenic Agent Bevacizumab in the Treatment of Elderly Patients with Metastatic Colorectal Cancer

被引：0
作者：
Maria Di Bartolomeo
Filippo Pietrantonio
Antonia Martinetti
Roberto Buzzoni
Arpine Gevorgyan
Emilio Bajetta
机构：
[1] Fondazione IRCCS Istituto Nazionale dei Tumori,Medical Oncology Unit 2
来源：
Drugs & Aging | 2011年 / 28卷
关键词：
Vascular Endothelial Growth Factor; Bevacizumab; Capecitabine; Metastatic Colorectal Cancer; mCRC Patient;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Although major progress has been achieved in the treatment of metastatic colorectal cancer with the employment of biological antiangiogenic agents, several questions remain open for discussion regarding the use of this therapy in elderly patients with metastatic colorectal cancer.
引用
收藏
页码：83 / 91
页数：8
相关论文
共 112 条
[1]  
Talarico L(2004)Enrollment of elderly patients in clinical trials for cancer drug registration: a 7-year experience by the US Food and Drug Administration J Clin Oncol 22 4626-31
[2]  
Chen G(2003)Participation of patients 65 years ofage or older in cancer clinical trials J Clin Oncol 21 1383-9
[3]  
Pazdur R(2005)5-Fluorouracil-based chemotherapy for advanced colorectal cancer in elderly patients: a North Central Cancer Treatment Group study Clin Colorectal Cancer 4 325-31
[4]  
Lewis JH(2009)Half of elderly patients routinely treated for colorectal cancer receive a sub-standard treatment Crit Rev Oncol Hematol 71 249-57
[5]  
Kilgore ML(1999)Adjuvant or palliative chemotherapy for colorectal cancer in patients 70 years or older J Clin Oncol 17 2412-8
[6]  
Goldman DP(2005)Improvement in colorectal cancer survival: a population-based study Eur J Cancer 41 2297-303
[7]  
D’Andre S(2004)Efficacy of 5-fluorouracil-based chemotherapy in elderly patients with metastatic colorectal cancer: a pooled analysis of clinical trials Ann Oncol 15 1330-8
[8]  
Sargent DJ(2008)Irinotecan/fluorouracil combination in first-line therapy of older and younger patients with metastatic colorectal cancer: combined analysis of 2,691 patients in randomized controlled trials J Clin Oncol 26 1443-51
[9]  
Cha SS(2006)Pooled analysis ofsafety and efficacy ofoxaliplatin plus fluorouracil/leucovorin administered bimonthly in elderly patients with colorectal cancer J Clin Oncol 24 4085-91
[10]  
Aparicio T(2005)Safety and efficacy of two different doses of capecitabine in the treatment of advanced breast cancer in older women J Clin Oncol 23 2155-61
12345678910