Chemical structure and biological activity of steroidal saponins from Furcraea gigantea

被引：6

作者：

Pereira Da Silva B. ^{[1
]}

Oliveira Campos P. ^{[1
]}

Paz Parente J. ^{[1
]}

机构：

[1] Laboratorio de Quimica de Plantas Medicinais, Nucleo de Pesquisas de Produtos Naturais, Universidade Federal Do Rio de Janeiro, CEP 21944-970, Rio de Janeiro

来源：

Chemistry of Natural Compounds | 2006年 / 42卷 / 3期

关键词：

Biological activity; Furcraea gigantea; Steroidal saponins; Structural elucidation;

D O I：

10.1007/s10600-006-0109-3

中图分类号：

学科分类号：

摘要：

A new bisdesmosidic furostanol saponin, along with a known spirostanol saponin, furcreastatin, were isolated from Furcraea gigantea Vent. (Agavaceae). The structure of the new saponin was elucidated as 3-[(O-6-deoxy-α-L- mannopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1å 3)-O-[O-β-D-glucopyranosyl-(1→3)-β-D-glucopyranosyl-(1→2) -O-β-D-glucopyranosyl-(1→4)-β-D-galactopyranosyl)oxy]-(3β, 5α, 25R)-26-(β-D-glucopyranosyloxy)-22-hydroxyfurost-12-one. The structural identification was performed using a combination of spectroscopic techniques and chemical conversions. Furcreastatin showed a powerful haemolytic effect in the in vitro assay, but the new bisdesmosidic furostanol saponin demonstrated only a significant inhibition of the capillary permeability activity. ©2006 Springer Science+Business Media, Inc.

引用

页码：316 / 321

页数：5

共 17 条

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